Sumit Mehra1, Anne B Chang2, Chor K Lam3, Stuart Campbell4, Joy J Mingi5, Izaak Thomas6, Suzanne Harwood7, Graeme Maguire8, Subash Heraganahally9. 1. Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia; and Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gardiner Hospital, Perth, Western Australia, Australia dr.sumitmehra1@gmail.com. 2. Child Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia; Department of Respiratory and Sleep Medicine, Queensland Children's Hospital, Brisbane, Queensland, Australia; and Center of Children's Health Research, Australian Centre For Health Services Innovation, Queensland University of Technology, Brisbane, Queensland, Australia anne.chang@menzies.edu.au. 3. Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia; and College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia lammaree@gmail.com. 4. Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia; Department of General Medicine, Gold Coast University Hospital, Southport, Queensland, Australia; and School of Medicine, Griffith University, Southport, Queensland, Australia stuartc345@gmail.com. 5. Department of Public Health, Charles Darwin University, Darwin, Northern Territory, Australia; and Darwin Respiratory and Sleep Health, Darwin Private Hospital, Darwin, Northern Territory, Australia joyjjose@yahoo.com. 6. Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia izaakh.thomas@nt.gov.au. 7. Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia suzanne.harwood@malala.com.au. 8. Melbourne Medical School, The University of Melbourne, Victoria, Australia graeme.maguire@wh.org.au. 9. Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia; College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia; and Darwin Respiratory and Sleep Health, Darwin Private Hospital, Darwin, Northern Territory, Australia hssubhashcmc@hotmail.com.
Abstract
INTRODUCTION: Chronic respiratory disorders are highly prevalent among Australian Aboriginal people living in the Top End Health Service region in the Northern Territory, Australia. Bronchiectasis is a heterogenous disease that features among these chronic respiratory conditions in this population. However, there are sparse comparative data between Aboriginal and non-Aboriginal patients with bronchiectasis from this region. METHODS: In this retrospective study, demographics, clinical characteristics and relevant laboratory parameters were compared among adult Aboriginal and non-Aboriginal patients diagnosed with bronchiectasis between 2012 and 2017. RESULTS: A total of 388 adults had radiology-confirmed bronchiectasis and 258 (66%) were Aboriginal. Compared to non-Aboriginal patients, Aboriginal patients were significantly younger (mean age 54 v 67 years), the majority lived in rural and remote communities (80% v 9 %), had higher rates of self-reported smoking (52% v 19%), alcohol consumption (29% v 12%) and co-occurrence of chronic obstructive pulmonary disease (65% v 38%) and other chronic co-morbidities. Sputum microbiology was also different between the groups with Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis being more common in Aboriginal patients, while Pseudomonas aeruginosa, Aspergillus species and non-tuberculous mycobacteria were higher in non-Aboriginal patients. Further, Aboriginal patients had poorer lung function compared to non-Aboriginal patients (forced expiratory volume after 1 second predicted 33% v 53%, forced vital capacity predicted 49% v 60% respectively), higher exacerbation rates (29% v 18%) and poorer overall outcomes (age at death 60 v 76 years). CONCLUSION: Within a single health service, Aboriginal patients with bronchiectasis have significantly poorer outcomes with differing manifestations and higher comorbidities than non-Aboriginal patients. This warrants further studies to identify feasible interventions to reduce this inequity.
INTRODUCTION: Chronic respiratory disorders are highly prevalent among Australian Aboriginal people living in the Top End Health Service region in the Northern Territory, Australia. Bronchiectasis is a heterogenous disease that features among these chronic respiratory conditions in this population. However, there are sparse comparative data between Aboriginal and non-Aboriginal patients with bronchiectasis from this region. METHODS: In this retrospective study, demographics, clinical characteristics and relevant laboratory parameters were compared among adult Aboriginal and non-Aboriginal patients diagnosed with bronchiectasis between 2012 and 2017. RESULTS: A total of 388 adults had radiology-confirmed bronchiectasis and 258 (66%) were Aboriginal. Compared to non-Aboriginal patients, Aboriginal patients were significantly younger (mean age 54 v 67 years), the majority lived in rural and remote communities (80% v 9 %), had higher rates of self-reported smoking (52% v 19%), alcohol consumption (29% v 12%) and co-occurrence of chronic obstructive pulmonary disease (65% v 38%) and other chronic co-morbidities. Sputum microbiology was also different between the groups with Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis being more common in Aboriginal patients, while Pseudomonas aeruginosa, Aspergillus species and non-tuberculous mycobacteria were higher in non-Aboriginal patients. Further, Aboriginal patients had poorer lung function compared to non-Aboriginal patients (forced expiratory volume after 1 second predicted 33% v 53%, forced vital capacity predicted 49% v 60% respectively), higher exacerbation rates (29% v 18%) and poorer overall outcomes (age at death 60 v 76 years). CONCLUSION: Within a single health service, Aboriginal patients with bronchiectasis have significantly poorer outcomes with differing manifestations and higher comorbidities than non-Aboriginal patients. This warrants further studies to identify feasible interventions to reduce this inequity.
Authors: Dorothy F L Sze; Timothy P Howarth; Clair D Lake; Helmi Ben Saad; Subash S Heraganahally Journal: Int J Chron Obstruct Pulmon Dis Date: 2022-04-21
Authors: Arijeet Pal; Timothy P Howarth; Chris Rissel; Raelene Messenger; Siji Issac; Linda Ford; Christine Connors; Subash Heraganahally Journal: BMJ Open Respir Res Date: 2022-08
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