OBJECTIVES: Data regarding the safety of endoscopic retrograde pancreatography (ERP) are limited compared with biliary endoscopic retrograde cholangiopancreatography. The aim of this study was to determine adverse events (AEs) associated with therapeutic ERP. METHODS: This single-center retrospective study examined consecutive therapeutic ERPs with the primary intention of cannulating the pancreatic duct. Multivariate logistic regression was performed to identify risk factors for AEs. RESULTS: A total of 3023 ERPs were performed in 1288 patients (mean age, 50.3 years; 57.8% female) from January 2000 to January 2017. Overall AE rate was 18.9% with abdominal pain requiring admission (9.8%) and post-ERP pancreatitis (5.7%) being most common. On multivariate analysis, female sex (adjusted odds ratio [aOR], 2.3; 95% confidence interval [CI], 1.9-2.9), acute recurrent pancreatitis (aOR, 5.0; 95% CI, 1.7-15.3), chronic pancreatitis (aOR, 1.8; 95% CI, 1.3-2.6), and pancreatic sphincter of Oddi dysfunction (aOR, 2.1; 95% CI, 1.4-3.3) were associated with an increased risk of overall AEs. Pancreatic sphincterotomy (aOR, 1.9; 95% CI, 1.5-2.4) and therapeutic stenting (aOR, 1.6; 95% CI, 1.2-2.2) also increased the risk of AEs. CONCLUSIONS: Nearly 1 in 5 patients who undergo therapeutic ERP will experience an AE; however, the rates of major AEs, including post-ERP pancreatitis, bleeding, and perforation, are low.
OBJECTIVES: Data regarding the safety of endoscopic retrograde pancreatography (ERP) are limited compared with biliary endoscopic retrograde cholangiopancreatography. The aim of this study was to determine adverse events (AEs) associated with therapeutic ERP. METHODS: This single-center retrospective study examined consecutive therapeutic ERPs with the primary intention of cannulating the pancreatic duct. Multivariate logistic regression was performed to identify risk factors for AEs. RESULTS: A total of 3023 ERPs were performed in 1288 patients (mean age, 50.3 years; 57.8% female) from January 2000 to January 2017. Overall AE rate was 18.9% with abdominal pain requiring admission (9.8%) and post-ERP pancreatitis (5.7%) being most common. On multivariate analysis, female sex (adjusted odds ratio [aOR], 2.3; 95% confidence interval [CI], 1.9-2.9), acute recurrent pancreatitis (aOR, 5.0; 95% CI, 1.7-15.3), chronic pancreatitis (aOR, 1.8; 95% CI, 1.3-2.6), and pancreatic sphincter of Oddi dysfunction (aOR, 2.1; 95% CI, 1.4-3.3) were associated with an increased risk of overall AEs. Pancreatic sphincterotomy (aOR, 1.9; 95% CI, 1.5-2.4) and therapeutic stenting (aOR, 1.6; 95% CI, 1.2-2.2) also increased the risk of AEs. CONCLUSIONS: Nearly 1 in 5 patients who undergo therapeutic ERP will experience an AE; however, the rates of major AEs, including post-ERP pancreatitis, bleeding, and perforation, are low.
Authors: P B Cotton; G Lehman; J Vennes; J E Geenen; R C Russell; W C Meyers; C Liguory; N Nickl Journal: Gastrointest Endosc Date: 1991 May-Jun Impact factor: 9.427
Authors: Peter B Cotton; Glenn M Eisen; Lars Aabakken; Todd H Baron; Matt M Hutter; Brian C Jacobson; Klaus Mergener; Albert Nemcek; Bret T Petersen; John L Petrini; Irving M Pike; Linda Rabeneck; Joseph Romagnuolo; John J Vargo Journal: Gastrointest Endosc Date: 2010-03 Impact factor: 9.427
Authors: Vinay Chandrasekhara; Krishnavel V Chathadi; Ruben D Acosta; G Anton Decker; Dayna S Early; Mohamad A Eloubeidi; John A Evans; Ashley L Faulx; Robert D Fanelli; Deborah A Fisher; Kimberly Foley; Lisa Fonkalsrud; Joo Ha Hwang; Terry L Jue; Mouen A Khashab; Jenifer R Lightdale; V Raman Muthusamy; Shabana F Pasha; John R Saltzman; Ravi Sharaf; Aasma Shaukat; Amandeep K Shergill; Amy Wang; Brooks D Cash; John M DeWitt Journal: Gastrointest Endosc Date: 2015-06-12 Impact factor: 9.427
Authors: Vinay Chandrasekhara; Mouen A Khashab; V Raman Muthusamy; Ruben D Acosta; Deepak Agrawal; David H Bruining; Mohamad A Eloubeidi; Robert D Fanelli; Ashley L Faulx; Suryakanth R Gurudu; Shivangi Kothari; Jenifer R Lightdale; Bashar J Qumseya; Aasma Shaukat; Amy Wang; Sachin B Wani; Julie Yang; John M DeWitt Journal: Gastrointest Endosc Date: 2016-08-18 Impact factor: 9.427
Authors: M L Freeman; D B Nelson; S Sherman; G B Haber; M E Herman; P J Dorsher; J P Moore; M B Fennerty; M E Ryan; M J Shaw; J D Lande; A M Pheley Journal: N Engl J Med Date: 1996-09-26 Impact factor: 91.245
Authors: Sachin Wani; Rajesh N Keswani; Samuel Han; Eva M Aagaard; Matthew Hall; Violette Simon; Wasif M Abidi; Subhas Banerjee; Todd H Baron; Michael Bartel; Erik Bowman; Brian C Brauer; Jonathan M Buscaglia; Linda Carlin; Amitabh Chak; Hemant Chatrath; Abhishek Choudhary; Bradley Confer; Gregory A Coté; Koushik K Das; Christopher J DiMaio; Andrew M Dries; Steven A Edmundowicz; Abdul Hamid El Chafic; Ihab El Hajj; Swan Ellert; Jason Ferreira; Anthony Gamboa; Ian S Gan; Lisa M Gangarosa; Bhargava Gannavarapu; Stuart R Gordon; Nalini M Guda; Hazem T Hammad; Cynthia Harris; Sujai Jalaj; Paul S Jowell; Sana Kenshil; Jason Klapman; Michael L Kochman; Srinadh Komanduri; Gabriel Lang; Linda S Lee; David E Loren; Frank J Lukens; Daniel Mullady; V Raman Muthusamy; Andrew S Nett; Mojtaba S Olyaee; Kavous Pakseresht; Pranith Perera; Patrick Pfau; Cyrus Piraka; John M Poneros; Amit Rastogi; Anthony Razzak; Brian Riff; Shreyas Saligram; James M Scheiman; Isaiah Schuster; Raj J Shah; Rishi Sharma; Joshua P Spaete; Ajaypal Singh; Muhammad Sohail; Jayaprakash Sreenarasimhaiah; Tyler Stevens; James H Tabibian; Demetrios Tzimas; Dushant S Uppal; Shiro Urayama; Domenico Vitterbo; Andrew Y Wang; Wahid Wassef; Patrick Yachimski; Sergio Zepeda-Gomez; Tobias Zuchelli; Dayna Early Journal: Gastroenterology Date: 2018-07-26 Impact factor: 22.682
Authors: M L Freeman; J A DiSario; D B Nelson; M B Fennerty; J G Lee; D J Bjorkman; C S Overby; J Aas; M E Ryan; G S Bochna; M J Shaw; H W Snady; R V Erickson; J P Moore; J P Roel Journal: Gastrointest Endosc Date: 2001-10 Impact factor: 9.427
Authors: Elham Afghani; Venkata S Akshintala; Mouen A Khashab; Joanna K Law; Susan M Hutfless; Katherine J Kim; Anne Marie Lennon; Anthony N Kalloo; Vikesh K Singh Journal: Endoscopy Date: 2014-05-15 Impact factor: 10.093