Pil Wook Chung1, Byung Su Kim2, Jeong Wook Park3, Jong Hee Sohn4, Mi Ji Lee5, Byung Kun Kim6, Min Kyung Chu7, Jin Young Ahn8, Yun Ju Choi9, Tae Jin Song10, Dae Woong Bae11, Daeyoung Kim12, Jae Moon Kim12, Soo Kyoung Kim13, Kwang Yeol Park14, Jae Myun Chung15, Heui Soo Moon1, Kyungmi Oh16, Chin Sang Chung5, Soo Jin Cho17. 1. Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. 2. Department of Neurology, Bundang Jesaeng General Hospital, Daejin Medical Center, Seongnam, Korea. 3. Department of Neurology, Uijeongbu St. Mary's Hospital, Uijeongbu, Korea. 4. Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea. 5. Department of Neurology, Neuroscience Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. 6. Department of Neurology, Nowon Eulji Medical Center, Eulji University, Seoul, Korea. 7. Department of Neurology, Severance Hospital, Seoul, Korea. 8. Department of Neurology, Seoul Medical Center, Seoul, Korea. 9. Department of Neurology, Dr. Choi's Neurology Clinic, Jeonju, Korea. 10. Department of Neurology, Ewha Womans University School of Medicine, Seoul, Korea. 11. Department of Neurology, College of Medicine, The Catholic University of Korea, Suwon, Korea. 12. Department of Neurology, Chungnam National University College of Medicine, Daejeon, Korea. 13. Department of Neurology, Gyeongsang National University College of Medicine, Jinju, Korea. 14. Department of Neurology, Chung-Ang University College of Medicine, Seoul, Korea. 15. Department of Neurology, Inje University College of Medicine, Seoul, Korea. 16. Department of Neurology, Korea University College of Medicine, Seoul, Korea. 17. Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea. dowonc@naver.com.
Abstract
BACKGROUND AND PURPOSE: Epidemiologic data suggest that cluster headache (CH) is significantly associated with cigarette smoking. The aim of this study was to determine differences in features between patients with a smoking history and those who are never-smokers, using data from a prospective multicenter registry. METHODS: Data used in this study were obtained from the Korean Cluster Headache Registry that collected data from consecutive patients diagnosed with CH. We compared clinical and demographic features between ever-smokers (current or former smokers) and never-smokers. RESULTS: This study enrolled 250 patients who were diagnosed with CH, of which 152 (60.8%) were ever-smokers and 98 (39.2%) were never-smokers. The age at CH onset was significantly lower in the never-smoker group than in the ever-smoker group [27.1±12.9 years vs. 30.6±10.9 years (mean±standard deviation), p=0.024]. Seasonal rhythmicity (58.1% vs. 44.7%, p=0.038) and triptan responsiveness (100% vs. 85.1%, p=0.001) were higher in never-smokers, while other clinical features such as pain severity, duration, attack frequency, and associated autonomic symptoms did not differ significantly between the groups. The male-to-female ratio was markedly higher in ever-smokers (29.4:1) than in never-smokers (1.7:1). CONCLUSIONS: Most of the clinical features did not differ significantly between patients with a smoking history and never-smokers. However, the age at CH onset, sex ratio, and seasonal rhythmicity were significantly associated with smoking history.
BACKGROUND AND PURPOSE: Epidemiologic data suggest that cluster headache (CH) is significantly associated with cigarette smoking. The aim of this study was to determine differences in features between patients with a smoking history and those who are never-smokers, using data from a prospective multicenter registry. METHODS: Data used in this study were obtained from the Korean Cluster Headache Registry that collected data from consecutive patients diagnosed with CH. We compared clinical and demographic features between ever-smokers (current or former smokers) and never-smokers. RESULTS: This study enrolled 250 patients who were diagnosed with CH, of which 152 (60.8%) were ever-smokers and 98 (39.2%) were never-smokers. The age at CH onset was significantly lower in the never-smoker group than in the ever-smoker group [27.1±12.9 years vs. 30.6±10.9 years (mean±standard deviation), p=0.024]. Seasonal rhythmicity (58.1% vs. 44.7%, p=0.038) and triptan responsiveness (100% vs. 85.1%, p=0.001) were higher in never-smokers, while other clinical features such as pain severity, duration, attack frequency, and associated autonomic symptoms did not differ significantly between the groups. The male-to-female ratio was markedly higher in ever-smokers (29.4:1) than in never-smokers (1.7:1). CONCLUSIONS: Most of the clinical features did not differ significantly between patients with a smoking history and never-smokers. However, the age at CH onset, sex ratio, and seasonal rhythmicity were significantly associated with smoking history.