| Literature DB >> 33835145 |
Junjie Zhao1, William Miller-Little1,2, Xiaoxia Li1.
Abstract
AIM2 is widely known for its role as a cytosolic dsDNA receptor that activates the inflammasome. In this issue of JEM, Ma et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201796) describe an inflammasome-independent function of AIM2 in microglia that restrains neuroinflammation via a novel crosstalk between AIM2 and cGAS signaling.Entities:
Year: 2021 PMID： 33835145 DOI： 10.1084/jem.20210273
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307