| Literature DB >> 33834610 |
Neelima Anup1, Tejas Chavan1, Shruti Chavan1, Suryanarayana Polaka1, Dnyaneshwar Kalyane1, Sara Nidal Abed2, Katharigatta N Venugopala3,4, Kiran Kalia1, Rakesh K Tekade1.
Abstract
Electrospun technology becomes a valuable means of fabricating functional polymeric nanofibers with distinctive morphological properties for drug delivery applications. Nanofibers are prepared from the polymer solution, which allows the direct incorporation of therapeutics such as small drug molecules, genes, and proteins by merely mixing them into the polymeric solution. Due to their biocompatibility, adhesiveness, sterility, and efficiency in delivering diverse cargoes, electrospun nanofibers have gained much attention. This review discusses the capabilities of the electrospun nanofibers in delivering different therapeutics like small molecules, genes, and proteins to their desired target site for treating various ailments. The potential of nanofibers in administering through multiple administration routes and the associated challenges has also been expounded along with a cross-talk about the commercial products of nanofibers for biomedical applications.Entities:
Keywords: drug delivery; electrospinning; nanofiber composite; therapeutics
Mesh:
Substances:
Year: 2021 PMID: 33834610 DOI: 10.1002/jbm.a.37187
Source DB: PubMed Journal: J Biomed Mater Res A ISSN: 1549-3296 Impact factor: 4.396