Haibo Chen1, Zhenyuan Zhai2, Qinghai Xie1, Yuanbin Lai1, Guiping Chen3. 1. The Department of Gynecology, Longyan People Hospital, Longyan, 364000, Fujian, China. 2. The Department of Gynecology, Weihai Central Hospital, Weihai, 264400, Shandong, China. 3. The Department of Gynecology, Longyan People Hospital, Longyan, 364000, Fujian, China. chenguiping1125@163.com.
Abstract
OBJECTIVE: To study the correlation between SNPs at phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) rs9838117 site, erb-b2 receptor tyrosine kinase 2 (ERBB2) rs1058808 site, and their interactions with environmental factors and the epithelial ovarian cancer (EOC) risk. METHODS: Sanger sequencing was used to analyze the genotypes of PIK3CA rs9838117 and ERBB2 rs1058808 site in 587 patients with epithelial ovarian cancer (EOC). Multi-factor dimensionality reduction (MDR) was applied to analyze the interaction between PIK3CA rs9838117 and ERBB2 rs1058808 site and the clinical data. RESULTS: The risk of EOC in T allele carriers at PIK3CA rs9838117 was 1.95 times (95%CI: 1.55-2.46, P<0.01) that of G allele carriers. The risk of EOC in G allele carriers at ERBB2 rs1058808 was as 0.64 times (95%CI: 0.54-0.75, P <0.01) as the risk for C allele carriers. In the interaction model between clinical data, PIK3CA rs9838117 site and ERBB2 rs1058808 SNP site, EOC risk in high-risk combination was 3.10 times (95%CI: 1.49-6.46, P <0.01) that of low-risk combination. CONCLUSION: The SNPs at PIK3CA rs9838117 and ERBB2 rs1058808 loci were associated with the risk of EOC.
OBJECTIVE: To study the correlation between SNPs at phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) rs9838117 site, erb-b2 receptor tyrosine kinase 2 (ERBB2) rs1058808 site, and their interactions with environmental factors and the epithelial ovarian cancer (EOC) risk. METHODS: Sanger sequencing was used to analyze the genotypes of PIK3CA rs9838117 and ERBB2 rs1058808 site in 587 patients with epithelial ovarian cancer (EOC). Multi-factor dimensionality reduction (MDR) was applied to analyze the interaction between PIK3CA rs9838117 and ERBB2 rs1058808 site and the clinical data. RESULTS: The risk of EOC in T allele carriers at PIK3CA rs9838117 was 1.95 times (95%CI: 1.55-2.46, P<0.01) that of G allele carriers. The risk of EOC in G allele carriers at ERBB2 rs1058808 was as 0.64 times (95%CI: 0.54-0.75, P <0.01) as the risk for C allele carriers. In the interaction model between clinical data, PIK3CA rs9838117 site and ERBB2 rs1058808 SNP site, EOC risk in high-risk combination was 3.10 times (95%CI: 1.49-6.46, P <0.01) that of low-risk combination. CONCLUSION: The SNPs at PIK3CA rs9838117 and ERBB2 rs1058808 loci were associated with the risk of EOC.
Authors: Asunción Díaz-Serrano; Barbara Angulo; Carolina Dominguez; Roberto Pazo-Cid; Antonieta Salud; Paula Jiménez-Fonseca; Ana Leon; Maria Carmen Galan; Maria Alsina; Fernando Rivera; J Carlos Plaza; Luis Paz-Ares; Fernando Lopez-Rios; Carlos Gómez-Martín Journal: Oncologist Date: 2018-04-26
Authors: Eyal Sheiner; Anil Kapur; Ravi Retnakaran; Eran Hadar; Liona C Poon; H David McIntyre; Hema Divakar; Anne Cathrine Staff; Jagat Narula; Anne B Kihara; Moshe Hod Journal: Int J Gynaecol Obstet Date: 2019-09 Impact factor: 3.561
Authors: Arezoo Astanehe; David Arenillas; Wyeth W Wasserman; Peter C K Leung; Sandra E Dunn; Barry R Davies; Gordon B Mills; Nelly Auersperg Journal: J Cell Sci Date: 2008-02-12 Impact factor: 5.285
Authors: Siddhartha P Kar; Andrew Berchuck; Simon A Gayther; Ellen L Goode; Kirsten B Moysich; Celeste Leigh Pearce; Susan J Ramus; Joellen M Schildkraut; Thomas A Sellers; Paul D P Pharoah Journal: Cancer Epidemiol Biomarkers Prev Date: 2017-06-14 Impact factor: 4.254
Authors: Yan Gao; Xiuwu Tang; Jieqin Cao; Rong Rong; Zhengmin Yu; Yang Liu; Yan Lu; Xiaowen Liu; Lei Han; Jiting Liu; Jun Zhang; Ming Xu; Fang Liu Journal: J Cancer Date: 2019-01-01 Impact factor: 4.207
Authors: K C Vázquez-Ibarra; A R Bustos-Carpinteyro; A García-Ruvalcaba; M T Magaãa-Torres; R Gutiérrez-Aguilar; M E Marín-Contreras; E Santiago-Luna; J Y Sánchez-López Journal: Braz J Med Biol Res Date: 2019-05-16 Impact factor: 2.590