D G Maimin1, M Laubscher2, S Maqungo2,3, L C Marais4. 1. Orthopaedic Research Unit (ORU), Division of Orthopaedic Surgery, University of Cape Town, H49, Old Main Building, Groote Schuur Hospital. Observatory., Cape Town, 7925, South Africa. danemaimin@gmail.com. 2. Orthopaedic Research Unit (ORU), Division of Orthopaedic Surgery, University of Cape Town, H49, Old Main Building, Groote Schuur Hospital. Observatory., Cape Town, 7925, South Africa. 3. Division of Global Surgery, University of Cape Town, Cape Town, South Africa. 4. Department of Orthopaedics, School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.
Abstract
BACKGROUND: The deleterious effects of hypoalbuminaemia in the peri-operative period are well documented. We aimed to review serum albumin levels in a cohort of orthopaedic trauma patients to determine the prevalence of hypoalbuminaemia. Secondarily, we aimed to identify factors associated with an increased risk of hypoalbuminaemia. METHODS: A retrospective cross-sectional study was performed of data collected prospectively at a regional hospital serving primarily a rural population in South Africa. RESULTS: Two hundred ninety-five patients were included in the study. Twenty-nine per cent of the cohort was found to have hypoalbuminaemia. Femur neck fractures (p < 0.001), intertrochanteric fractures (p = 0.004), tibial plateau fractures (p = 0.034) and polytrauma (p = 0.013) were associated with hypoalbuminaemia. The mean albumin level was lower in HIV-positive patients when compared to HIV-negative patients (35.7 g/L vs 37.5 g/L, p = 0.007). The presence of comorbidities other than HIV, like diabetes mellitus (p = 0.001), previous pulmonary tuberculosis (p = 0.034) and chronic renal failure (p = 0.007) was associated with hypoalbuminaemia. CONCLUSION: In this cohort of orthopaedic trauma patients from rural South Africa, we found a 29% prevalence of hypoalbuminaemia at the time of presentation. High-risk subgroups include patients with pre-existing comorbidities and increased age, as well as patients presenting with polytrauma, femoral neck, intertrochanteric femur or tibial plateau fractures.
BACKGROUND: The deleterious effects of hypoalbuminaemia in the peri-operative period are well documented. We aimed to review serum albumin levels in a cohort of orthopaedic trauma patients to determine the prevalence of hypoalbuminaemia. Secondarily, we aimed to identify factors associated with an increased risk of hypoalbuminaemia. METHODS: A retrospective cross-sectional study was performed of data collected prospectively at a regional hospital serving primarily a rural population in South Africa. RESULTS: Two hundred ninety-five patients were included in the study. Twenty-nine per cent of the cohort was found to have hypoalbuminaemia. Femur neck fractures (p < 0.001), intertrochanteric fractures (p = 0.004), tibial plateau fractures (p = 0.034) and polytrauma (p = 0.013) were associated with hypoalbuminaemia. The mean albumin level was lower in HIV-positive patients when compared to HIV-negative patients (35.7 g/L vs 37.5 g/L, p = 0.007). The presence of comorbidities other than HIV, like diabetes mellitus (p = 0.001), previous pulmonary tuberculosis (p = 0.034) and chronic renal failure (p = 0.007) was associated with hypoalbuminaemia. CONCLUSION: In this cohort of orthopaedic trauma patients from rural South Africa, we found a 29% prevalence of hypoalbuminaemia at the time of presentation. High-risk subgroups include patients with pre-existing comorbidities and increased age, as well as patients presenting with polytrauma, femoral neck, intertrochanteric femur or tibial plateau fractures.
Authors: Deena Kishawi; Garrett Schwarzman; Alfonso Mejia; Awais K Hussain; Mark H Gonzalez Journal: J Bone Joint Surg Am Date: 2020-05-20 Impact factor: 5.284
Authors: Setor K Kunutsor; Ari Voutilainen; Michael R Whitehouse; Samuel Seidu; Jussi Kauhanen; Ashley W Blom; Jari A Laukkanen Journal: Med Princ Pract Date: 2019-03-21 Impact factor: 1.927
Authors: Jacob M Wilson; Matthew P Lunati; Zachary J Grabel; Christopher A Staley; Andrew M Schwartz; Mara L Schenker Journal: J Orthop Trauma Date: 2019-06 Impact factor: 2.512
Authors: Richard Matzopoulos; Megan Prinsloo; Victoria Pillay-van Wyk; Nomonde Gwebushe; Shanaaz Mathews; Lorna J Martin; Ria Laubscher; Naeemah Abrahams; William Msemburi; Carl Lombard; Debbie Bradshaw Journal: Bull World Health Organ Date: 2015-03-13 Impact factor: 9.408
Authors: Juanita A Haagsma; Nicholas Graetz; Ian Bolliger; Mohsen Naghavi; Hideki Higashi; Erin C Mullany; Semaw Ferede Abera; Jerry Puthenpurakal Abraham; Koranteng Adofo; Ubai Alsharif; Emmanuel A Ameh; Walid Ammar; Carl Abelardo T Antonio; Lope H Barrero; Tolesa Bekele; Dipan Bose; Alexandra Brazinova; Ferrán Catalá-López; Lalit Dandona; Rakhi Dandona; Paul I Dargan; Diego De Leo; Louisa Degenhardt; Sarah Derrett; Samath D Dharmaratne; Tim R Driscoll; Leilei Duan; Sergey Petrovich Ermakov; Farshad Farzadfar; Valery L Feigin; Richard C Franklin; Belinda Gabbe; Richard A Gosselin; Nima Hafezi-Nejad; Randah Ribhi Hamadeh; Martha Hijar; Guoqing Hu; Sudha P Jayaraman; Guohong Jiang; Yousef Saleh Khader; Ejaz Ahmad Khan; Sanjay Krishnaswami; Chanda Kulkarni; Fiona E Lecky; Ricky Leung; Raimundas Lunevicius; Ronan Anthony Lyons; Marek Majdan; Amanda J Mason-Jones; Richard Matzopoulos; Peter A Meaney; Wubegzier Mekonnen; Ted R Miller; Charles N Mock; Rosana E Norman; Ricardo Orozco; Suzanne Polinder; Farshad Pourmalek; Vafa Rahimi-Movaghar; Amany Refaat; David Rojas-Rueda; Nobhojit Roy; David C Schwebel; Amira Shaheen; Saeid Shahraz; Vegard Skirbekk; Kjetil Søreide; Sergey Soshnikov; Dan J Stein; Bryan L Sykes; Karen M Tabb; Awoke Misganaw Temesgen; Eric Yeboah Tenkorang; Alice M Theadom; Bach Xuan Tran; Tommi J Vasankari; Monica S Vavilala; Vasiliy Victorovich Vlassov; Solomon Meseret Woldeyohannes; Paul Yip; Naohiro Yonemoto; Mustafa Z Younis; Chuanhua Yu; Christopher J L Murray; Theo Vos Journal: Inj Prev Date: 2015-12-03 Impact factor: 2.399