Frances F Diehl1, Matthew G Vander Heiden2,3. 1. Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. 2. Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. mvh@mit.edu. 3. Dana-Farber Cancer Institute, Boston, MA, USA. mvh@mit.edu.