Literature DB >> 33833324

Untuned broadband spiral micro-coils achieve sensitive multi-nuclear NMR TX/RX from microfluidic samples.

Hossein Davoodi1, Nurdiana Nordin1,2, Hirokazu Munakata3, Jan G Korvink1, Neil MacKinnon4, Vlad Badilita5.   

Abstract

The low frequency plateau in the frequency response of an untuned micro-resonator permits broadband radio-frequency reception, albeit at the expense of optimal signal-to-noise ratio for a particular nucleus. In this contribution we determine useful figures of merit for broadband micro-coils, and thereby explore the parametric design space towards acceptable simultaneous excitation and reception of a microfluidic sample over a wide frequency band ranging from 13C to 1H, i.e., 125-500 MHz in an 11.74 T magnet. The detector achieves 37% of the performance of a comparably sized, tuned and matched resonator, and a linewidth of 17 ppb using standard magnet shims. The use of broadband detectors circumvents numerous difficulties introduced by multi-resonant RF detector circuits, including sample loading effects on matching, channel isolation, and field distortion.

Entities:  

Year:  2021        PMID: 33833324     DOI: 10.1038/s41598-021-87247-2

Source DB:  PubMed          Journal:  Sci Rep        ISSN: 2045-2322            Impact factor:   4.379


  36 in total

1.  The way to NMR structures of proteins.

Authors:  K Wüthrich
Journal:  Nat Struct Biol       Date:  2001-11

2.  Quantitative solid-state 13C NMR with signal enhancement by multiple cross polarization.

Authors:  Robert L Johnson; Klaus Schmidt-Rohr
Journal:  J Magn Reson       Date:  2013-11-27       Impact factor: 2.229

Review 3.  Pure shift NMR.

Authors:  Klaus Zangger
Journal:  Prog Nucl Magn Reson Spectrosc       Date:  2015-02-12       Impact factor: 9.795

Review 4.  Broadband and multi-resonant sensors for NMR.

Authors:  Hossein Davoodi; Mazin Jouda; Jan G Korvink; Neil MacKinnon; Vlad Badilita
Journal:  Prog Nucl Magn Reson Spectrosc       Date:  2019-05-10       Impact factor: 9.795

5.  Double-resonance circuit for nuclear magnetic resonance spectroscopy.

Authors:  P Tang; W J Chien; G S Harbison
Journal:  Solid State Nucl Magn Reson       Date:  1993-12       Impact factor: 2.293

6.  Parallel acquisition of two-dimensional NMR spectra of several nuclear species.

Authors:  Eriks Kupce; Ray Freeman; Boban K John
Journal:  J Am Chem Soc       Date:  2006-08-02       Impact factor: 15.419

7.  Three-dimensional structure of the transmembrane domain of Vpu from HIV-1 in aligned phospholipid bicelles.

Authors:  Sang Ho Park; Anna A De Angelis; Alexander A Nevzorov; Chin H Wu; Stanley J Opella
Journal:  Biophys J       Date:  2006-07-21       Impact factor: 4.033

8.  Design of small volume HX and triple-resonance probes for improved limits of detection in protein NMR experiments.

Authors:  Yu Li; Timothy M Logan; Arthur S Edison; Andrew Webb
Journal:  J Magn Reson       Date:  2003-09       Impact factor: 2.229

9.  TROSY in triple-resonance experiments: new perspectives for sequential NMR assignment of large proteins.

Authors:  M Salzmann; K Pervushin; G Wider; H Senn; K Wüthrich
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-10       Impact factor: 11.205

Review 10.  Modern Technologies of Solution Nuclear Magnetic Resonance Spectroscopy for Three-dimensional Structure Determination of Proteins Open Avenues for Life Scientists.

Authors:  Toshihiko Sugiki; Naohiro Kobayashi; Toshimichi Fujiwara
Journal:  Comput Struct Biotechnol J       Date:  2017-04-13       Impact factor: 7.271

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  1 in total

1.  Sample-centred shimming enables independent parallel NMR detection.

Authors:  Yen-Tse Cheng; Mazin Jouda; Jan Korvink
Journal:  Sci Rep       Date:  2022-08-19       Impact factor: 4.996

  1 in total

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