Literature DB >> 3383184

A new way to carcinogenicity of azo dyes: the benzenediazonium ion formed from a non-aminoazo dye, 1-phenylazo-2-hydroxynaphthalene(Sudan I) by microsomal enzymes binds to deoxyguanosine residues of DNA.

M Stiborová1, B Asfaw, P Anzenbacher, P Hodek.   

Abstract

1-Phenylazo-2-hydroxynaphthalene (Sudan I) activated by pre-incubation with microsomal enzymes of rat livers covalently binds to DNA from calf thymus. Benzenediazonium ion formed from Sudan I by activation with microsomal enzymes is the principal active metabolite, which binds to DNA. Enzymatic hydrolysis of modified (14C-labelled) DNA, followed by separation of deoxynucleosides on a Sephadex G-10 column revealed that deoxyguanosine is the principal target for the binding of activated Sudan I. The high-performance liquid chromatographic (HPLC) analysis indicate that probably more than one radioactive adduct of activated Sudan I with deoxyguanosine is formed.

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Year:  1988        PMID： 3383184     DOI： 10.1016/0304-3835(88)90092-4

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  4 in total

1.  Oxidation of the carcinogenic non-aminoazo dye 1-phenylazo-2-hydroxy-naphthalene (Sudan I) by cytochromes P450 and peroxidases: a comparative study.

Authors:  Marie Stiborová; Václav Martínek; Marcela Semanská; Petr Hodek; Martin Dračínský; Josef Cvačka; Heinz H Schmeiser; Eva Frei
Journal:  Interdiscip Toxicol       Date:  2009-09-28

2.  A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches.

Authors:  Marie Stiborová; František Bárta; Kateřina Levová; Petr Hodek; Heinz H Schmeiser; Volker M Arlt; Václav Martínek
Journal:  Int J Mol Sci       Date:  2015-11-18       Impact factor: 5.923

3.  Induced expression of microsomal cytochrome b5 determined at mRNA and protein levels in rats exposed to ellipticine, benzo[a]pyrene, and 1-phenylazo-2-naphthol (Sudan I).

Authors:  Marie Stiborová; Michaela Moserová; Iveta Mrízová; Helena Dračínská; Václav Martínek; Radek Indra; Eva Frei; Vojtěch Adam; René Kizek; Heinz H Schmeiser; Kateřina Kubáčková; Volker M Arlt
Journal:  Monatsh Chem       Date:  2016-01-12       Impact factor: 1.451

4.  Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo.

Authors:  Helena Dračínská; František Bárta; Kateřina Levová; Alena Hudecová; Michaela Moserová; Heinz H Schmeiser; Klaus Kopka; Eva Frei; Volker M Arlt; Marie Stiborová
Journal:  Toxicology       Date:  2016-02-01       Impact factor: 4.221
  4 in total

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