Literature DB >> 33831475

Microarray patches: Breaking down the barriers to contraceptive care and HIV prevention for women across the globe.

Alejandro J Paredes1, Inken K Ramöller1, Peter E McKenna1, Marco T A Abbate1, Fabiana Volpe-Zanutto1, Lalitkumar K Vora1, Maggie Kilbourne-Brook2, Courtney Jarrahian2, Kurtis Moffatt1, Chunyang Zhang1, Ismaiel A Tekko3, Ryan F Donnelly4.   

Abstract

Despite the existence of a variety of contraceptive products for women, as well as decades of research into the prevention and treatment of human immunodeficiency virus (HIV), there is still a globally unmet need for easily accessible, acceptable, and affordable products to protect women's sexual and reproductive health. Microarray patches (MAPs) are a novel platform being developed for the delivery of hormonal contraception and antiretroviral drugs. MAPs provide enhanced drug delivery to the systemic circulation via the transdermal route when compared to transdermal patches, oral and injectable formulations. These minimally invasive patches can be self-administered by the user, reducing the burden on health care personnel. Since MAPs represent needle-free drug delivery, no sharps waste is generated after application, thereby eliminating possible MAP reuse and risk of needle-stick injuries. This review discusses the administration of contraceptive and antiretroviral drugs using MAPs, their acceptability by end-users, and the future perspective of the field.
Copyright © 2021 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Contraception; HIV; Long-acting; Microneedles; Transdermal; Women’s health

Year:  2021        PMID: 33831475     DOI: 10.1016/j.addr.2021.04.002

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN: 0169-409X            Impact factor:   15.470


  4 in total

1.  Evaluating Islatravir Administered Via Microneedle Array Patch for Long-Acting HIV Pre-exposure Prophylaxis Using Physiologically Based Pharmacokinetic Modelling.

Authors:  Hannah Kinvig; Nicolas Cottura; Andrew Lloyd; Collrane Frivold; Jessica Mistilis; Courtney Jarrahian; Marco Siccardi
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2022-09-30       Impact factor: 2.569

2.  Models and methods to characterise levonorgestrel release from intradermally administered contraceptives.

Authors:  Adnan Al Dalaty; Benedetta Gualeni; Sion A Coulman; James C Birchall
Journal:  Drug Deliv Transl Res       Date:  2021-12-03       Impact factor: 4.617

3.  Nanoemulsion-based dissolving microneedle arrays for enhanced intradermal and transdermal delivery.

Authors:  Muhammad Iqbal Nasiri; Lalitkumar K Vora; Juhaina Abu Ershaid; Ke Peng; Ismaiel A Tekko; Ryan F Donnelly
Journal:  Drug Deliv Transl Res       Date:  2021-12-22       Impact factor: 4.617

4.  Systemic delivery of tenofovir alafenamide using dissolving and implantable microneedle patches.

Authors:  Alejandro J Paredes; Fabiana Volpe-Zanutto; Lalitkumar K Vora; Ismaiel A Tekko; Andi Dian Permana; Camila J Picco; Helen O McCarthy; Ryan F Donnelly
Journal:  Mater Today Bio       Date:  2022-02-11
  4 in total

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