Literature DB >> 33831136

Corrigendum: High-Dose Intravenous Immunoglobulin in Severe Coronavirus Disease 2019: A Multicenter Retrospective Study in China.

Wei Cao1, Xiaosheng Liu1,2,3, Ke Hong4, Zhiyong Ma5, Yuelun Zhang6, Ling Lin1, Yang Han1, Yong Xiong5, Zhengyin Liu1, Lianguo Ruan4, Taisheng Li1,2,3.   

Abstract

[This corrects the article DOI: 10.3389/fimmu.2021.627844/full.].
Copyright © 2021 Cao, Liu, Hong, Ma, Zhang, Lin, Han, Xiong, Liu, Ruan and Li.

Entities:  

Keywords:  28-day mortality; COVID-19; high-dose intravenous immunoglobulin; immunomodulation; inflammatory markers

Year:  2021        PMID: 33831136      PMCID: PMC8020904          DOI: 10.3389/fimmu.2021.671443

Source DB:  PubMed          Journal:  Front Immunol        ISSN: 1664-3224            Impact factor:   7.561


Error in Table

In the original article, there was a mistake in as published. The author identified the calculating errors in the percentage of comorbidity, symptoms, and treatment. The corrected appears below.
Table 1

Clinical and relevant baseline characteristics of patients.

CharacteristicTotal (n = 115)IVIg group (n = 26)Control group (n = 89)SD (%)
Demographics
Age, median (IQR)59 (47–69)58 (42–65)59 (48–70)16
Male sex, No. (%)76 (66)19 (73)57 (64)18
Any comorbidity, No. (%)
 Hypertension52 (45)10 (38)42 (47)9
 Diabetes24 (21)2 (8)22 (25)39
 Chronic cardiac disease18 (16)5 (19)13 (15)11
 Chronic respiratory disease11 (10)2 (8)9 (10)4
Any symptoms, No. (%)
 Fever111 (97)22 (85)89 (100)31
 Cough97 (84)22 (85)75 (84)8
 Dyspnea96 (83)22 (85)74 (83)10
 Fatigue or myalgia52 (45)9 (35)43 (48)19
 Diarrhea30 (26)4 (15)26 (29)24
Vital signs
 Systolic BP, mm Hg132 ± 19131 ± 14133 ± 205
 HR,/min88 (80–102)85 (81–100)89 (80–105)9
 RR, breaths/min22 (20–25)22 (20–23)22 (20–25)2
 SPO2, %90 (87–94)91 (89–94)89 (86–92)6
Complete blood count
 WBCs, × 109/L6.59 (4.38–9.64)6.25 (4.15–10.28)6.60 (4.42–9.56)4
 LYM, × 109/L0.76 (0.57–1.02)0.90 (0.62–1.05)0.73 (0.56–0.91)19
 PLT, × 109/L191 (148–269)172 (144–279)199 (150–270)18
Inflammatory biomarkers
 IL–6, pg/mL13.0 (8.0–31.5)15.5 (10.5–34.0)11.0 (7.2–32.2)15
 IL–8, pg/mL15.2 (6.0–27.3)16.2 (5.8–23.8)15.2 (5.9–28.4)3
 IL–10, pg/mL5.2 (5.0–10.3)5.0 (5.0–8.5)5.5 (5.0–11.2)2
 hsCRP, mg/L48 (17–94)28 (7–91)45 (17–101)14
 Ferritin, ng/mL807.0 (473.4–1383.3)774.1 (444.2–1525.4)838.8 (501.5–1351.1)18
 ESR, mm/h50 (25–65)35 (19–67)50 (27–65)14
Immunoglobulins
 IgA, g/L2.2 (1.8–3.0)2.7 (1.9–4.6)2.2 (1.6–3.0)2
 IgG, g/L11.1 (9.0–13.1)11.8 (8.5–15.7)11.1 (9.3–13.1)2
 IgM g/L1.0 (0.7–1.2)1.0 (0.9–1.1)0.9 (0.7–1.3)3
Seven–category scales at admission 4.0 ± 0.673.85 ± 0.674.06 ± 0.6626
 3, No. (%)20 (17)7 (27)13 (15)24
 4, No. (%)79 (69)17(65)62 (70)7
 5, No. (%)11 (10)1 (4)10 (11)25
 6, No. (%)5 (4)1 (4)4 (4)3
Murray lung injury scores at admission 3.93 ± 0.223.90 ± 0.283.94 ± 0.2011
Time to admission after onset, median (IQR) 10 (7–12)10 (7–12)10 (8–12)5
Earlier (< 7 days), No. (%)29 (25)7 (27)22 (25)12
Later (between 7–14 days), No. (%)86 (75)19 (73)67 (75)12
Treatment during hospitalization, No. (%)
 Antiviral treatment100 (87)22 (85)78 (88)7
 Arbidol75 (65)15 (58)60 (67)16
 IFN–α34 (30)14 (54)20 (22)53
 LPV/r31 (27)9 (35)22 (25)17
 RBV12 (10)3 (12)9 (10)4
 OSV33 (29)8 (31)25 (28)5
 Antibiotic treatment100 (87)25 (96)75 (84)37
 Moxifloxacin73 (63)15 (58)58 (65)12
 Cefoperazone and tazobactam47 (41)13 (50)34 (38)19
 Antifungal treatment11 (10)5 (19)6 (7)29
 TCM58 (50)15 (58)43 (48)15
 LMWH19 (16)4 (15)15 (17)3
 Glucocorticoids71 (62)18 (69)53 (60)17
IVIg therapy 26 (23)26 (100)0 (0)
Initiation time, days, median (IQR)2 (1–4)
Course, days, median (IQR)5 (5–9)
Amount, g, median (IQR)122.5 (95.0–213.8)

SD, standard deviation; Tmax, maximal temperature; BP, blood pressure; HR, heart rate; RR, respiratory rate; SPO2, pulse oximeter O2 saturation; WBC, white cell counts; LYM, lymphocyte counts; PLT, platelet counts; IL, interleukin; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; IFN-α, Interferon-alfa; LPV/r, lopinavir/ritonavir; RBV, ribavirin; OSV, oseltamivir; TCM, traditional Chinese medicine; LMWH, low molecular weight heparin.

Clinical and relevant baseline characteristics of patients. SD, standard deviation; Tmax, maximal temperature; BP, blood pressure; HR, heart rate; RR, respiratory rate; SPO2, pulse oximeter O2 saturation; WBC, white cell counts; LYM, lymphocyte counts; PLT, platelet counts; IL, interleukin; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; IFN-α, Interferon-alfa; LPV/r, lopinavir/ritonavir; RBV, ribavirin; OSV, oseltamivir; TCM, traditional Chinese medicine; LMWH, low molecular weight heparin. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
  1 in total

Review 1.  Intravenous immunoglobulin (IVIg) therapy in hospitalised adult COVID-19 patients: A systematic review and meta-analysis.

Authors:  Robert Marcec; Vinko Michael Dodig; Igor Radanovic; Robert Likic
Journal:  Rev Med Virol       Date:  2022-09-12       Impact factor: 11.043

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.