Literature DB >> 3383096

Grandchildren of survivors: can negative effects of prolonged exposure to excessive stress be observed two generations later?

J J Sigal1, V F DiNicola, M Buonvino.   

Abstract

Some studies have demonstrated negative psychological repercussions on children of parents who experienced extreme, prolonged stress. To determine whether such effects might continue in the third generation, we examined the presenting complaints of patients in a child psychiatry clinic who could be reliably identified as: (i) children whose parents were native born but who had at least one grandparent who was a survivor of the Nazi persecution (Index 1, N = 58); (ii) other children who had at least one parent and one grandparent who was a survivor (Index 2, N = 11); (iii) children of other immigrant grandparents (N = 28); (iv) children with four native born grandparents (N = 30). All other grandparents and parents were native born. All families were of the same ethnic group. Index 2 children manifested more difficulties related to school performance, but the small size of the sample precludes generalization. Although the Index 1 children did not have different types of behavioural disturbances, the size of the Index (1 + 2) group (N = 69) relative to the comparison groups was 300% greater than expected on the basis of community population estimates. Implications of this finding are discussed.

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Year:  1988        PMID: 3383096     DOI: 10.1177/070674378803300309

Source DB:  PubMed          Journal:  Can J Psychiatry        ISSN: 0706-7437            Impact factor:   4.356


  4 in total

Review 1.  Mechanisms of non-genetic inheritance and psychiatric disorders.

Authors:  Miklos Toth
Journal:  Neuropsychopharmacology       Date:  2014-06-03       Impact factor: 7.853

2.  The secret language of destiny: stress imprinting and transgenerational origins of disease.

Authors:  Fabiola C R Zucchi; Youli Yao; Gerlinde A Metz
Journal:  Front Genet       Date:  2012-06-04       Impact factor: 4.599

3.  Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms.

Authors:  Emma Mitchell; Shifra L Klein; Kimon V Argyropoulos; Ali Sharma; Robin B Chan; Judit Gal Toth; Luendreo Barboza; Charlotte Bavley; Analia Bortolozzi; Qiuying Chen; Bingfang Liu; Joanne Ingenito; Willie Mark; Jarrod Dudakov; Steven Gross; Gilbert Di Paolo; Francesc Artigas; Marcel van den Brink; Miklos Toth
Journal:  Nat Commun       Date:  2016-05-13       Impact factor: 14.919

4.  Pre-reproductive stress in adolescent female rats alters oocyte microRNA expression and offspring phenotypes: pharmacological interventions and putative mechanisms.

Authors:  Hiba Zaidan; Dalia Galiani; Inna Gaisler-Salomon
Journal:  Transl Psychiatry       Date:  2021-02-05       Impact factor: 6.222

  4 in total

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