| Literature DB >> 33830449 |
Satoru Takayama1,2, Miho Kawanishi3, Kosei Yamauchi3, Daiki Tokumitsu4, Hiroyuki Kojima5, Teruaki Masutani5, Arunasiri Iddamalgoda5, Tohru Mitsunaga3, Hiroyuki Tanaka6,7.
Abstract
The anti-inflammatory effects of a 50% aqueous extract of Rosa roxburghii fruit (RRFE) and two ellagitannins (strictinin and casuarictin) isolated from the RRFE were evaluated in a cell model of skin inflammation induced by self-RNA released from epidermal cells damaged by UV ray (UVR) irradiation. The RRFE inhibited interleukin-8 (IL-8) mRNA expression in normal human epidermal keratinocytes (NHEKs) stimulated with polyinosinic:polycytidylic acid (poly(I:C)), a ligand of toll-like receptor-3 (TLR-3). The plant-derived anti-inflammatory agents, dipotassium glycyrrhizinate (GK2) and allantoin, had no influence on the IL-8 expression. The purified compounds, strictinin and casuarictin, inhibited the IL-8 mRNA expression and IL-8 release induced in NHEKs by poly(I:C). These ellagitannins were thus found to be responsible for the biological activity exhibited by the RRFE. This study demonstrates that RRFE and isolated RRFE compounds show promise as ingredients for products formulated to improve skin disorders induced by UVR irradiation.Entities:
Keywords: Anti-inflammatory effects; Casuarictin; IL-8; Rosa roxburghii; Strictinin; TLR-3
Year: 2021 PMID： 33830449 DOI： 10.1007/s11418-021-01509-x
Source DB: PubMed Journal: J Nat Med ISSN： 1340-3443 Impact factor: 2.343