Variations in c-fos gene expression during rat brain development.

Expression of the c-fos proto-oncogene has been associated with mitosis or differentiation in a number of tissue culture model systems. We have studied the expression of this gene during in vivo brain development in the rat. Our results demonstrate that very low levels of c-fos mRNA are detectable during the period of development characterized by rapid mitosis, whereas much higher concentrations of c-fos mRNA are found in the brains of older neonatal animals and adults. Therefore, although c-fos could be participating in the regulation of mitosis during early postnatal development of the brain, it is also likely to play an important role in mature brain tissue.