| Literature DB >> 33827575 |
Paolo A Ascierto1, Michael B Atkins2, Alexander M Eggermont3, Jeffrey E Gershenwald4, Jean-Jacques Grob5, Omid Hamid6, Vernon K Sondak7,8, Jeffrey A Sosman9, Hussein A Tawbi10, Jeffrey S Weber11, Corrado Caracò12, Iman Osman13, Igor Puzanov14.
Abstract
The Great Debate session at the 2020 Melanoma Bridge virtual congress (December 3rd-5th, Italy) featured counterpoint views from experts on five specific controversial issues in melanoma. The debates considered whether or not innate immunity is important in the response to cancer and immunotherapy, how useful are the revised American Joint Committee on Cancer (AJCC) classification for the staging of patients, the use of sentinel node biopsy for staging patients, the use of triplet combination of targeted therapy plus immunotherapy versus combined immunotherapy, and the respective benefits of neoadjuvant versus adjuvant therapy. As is usual with Bridge congresses, the debates were assigned by meeting Chairs and positions taken by experts during the debates may not have necessarily reflected their own personal opinion.Entities:
Keywords: Adjuvant; Anti-CTLA-4; Anti-PD-1; BRAF inhibitor; Immunotherapy; MEK inhibitor; Melanoma; Neoadjuvant; Staging; Targeted therapy
Year: 2021 PMID: 33827575 DOI: 10.1186/s12967-021-02808-3
Source DB: PubMed Journal: J Transl Med ISSN: 1479-5876 Impact factor: 5.531