Literature DB >> 3382593

The influence of haematocrit on blood cyclosporin measurements in vivo.

A Johnston1, J T Marsden, D W Holt.   

Abstract

The influence of haematocrit on blood cyclosporin measurements has been studied in 276 paired blood and plasma samples from 21 renal transplant patients. A highly significant correlation was found between blood and plasma cyclosporin concentrations, r = 0.8744, but the correlation between blood or plasma cyclosporin and haematocrit was not significant. The ratio of blood/plasma cyclosporin did not significantly increase with increasing haematocrit. It was concluded that in vivo the influence of haematocrit on the measurement of blood cyclosporin concentrations was negligible.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 3382593      PMCID： PMC1387814          DOI： 10.1111/j.1365-2125.1988.tb03336.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  13 in total

1.  The United Kingdom Cyclosporin Quality Assessment Scheme.

Authors:  A Johnston; J T Marsden; D W Holt
Journal:  Ther Drug Monit       Date:  1986       Impact factor: 3.681

2.  Relationships of cyclosporine concentrations in serum, whole blood, and bile after renal and hepatic transplantation.

Authors:  W Vine; M W Flye; P Jatlow
Journal:  Clin Chem       Date:  1986-10       Impact factor: 8.327

3.  Role of lipoproteins and erythrocytes in the in vitro binding and distribution of cyclosporin A in the blood.

Authors:  M Lemaire; J P Tillement
Journal:  J Pharm Pharmacol       Date:  1982-11       Impact factor: 3.765

4.  Temperature dependency of apparent cyclosporin A concentrations in plasma.

Authors:  M Wenk; F Follath; E Abisch
Journal:  Clin Chem       Date:  1983-10       Impact factor: 8.327

5.  Cyclosporin concentrations in whole blood and plasma.

Authors:  M J Bennett; K H Carpenter; E Worthy; J S Lilleyman
Journal:  Clin Chem       Date:  1984-05       Impact factor: 8.327

6.  The value of serial serum trough cyclosporine levels in human renal transplantation.

Authors:  B D Kahan; C A Wideman; M Reid; S Gibbons; M Jarowenko; S Flechner; C T Van Buren
Journal:  Transplant Proc       Date:  1984-10       Impact factor: 1.066

7.  In vitro stability of cyclosporin A.

Authors:  J M Hows; J M Smith
Journal:  J Clin Pathol       Date:  1983-06       Impact factor: 3.411

8.  Effects of sample preparation on concentrations of cyclosporin A measured in plasma.

Authors:  R W Yatscoff; D N Rush; J R Jeffery
Journal:  Clin Chem       Date:  1984-11       Impact factor: 8.327

Review 9.  Critical issues in cyclosporine monitoring: report of the Task Force on Cyclosporine Monitoring.

Authors: 
Journal:  Clin Chem       Date:  1987-07       Impact factor: 8.327

10.  Assessment of cyclosporin A in whole blood and plasma in five patients with different hematocrits.

Authors:  R P Agarwal; R A McPherson; G A Threatte
Journal:  Ther Drug Monit       Date:  1985       Impact factor: 3.681
View more
  4 in total

Review 1.  Therapeutic drug monitoring of immunosuppressant drugs.

Authors:  A Johnston; D W Holt
Journal:  Br J Clin Pharmacol       Date:  1999-04       Impact factor: 4.335

2.  Feasibility of Using High-Contrast Grating as a Point-of-Care Sensor for Therapeutic Drug Monitoring of Immunosuppressants.

Authors:  Yi-Cheng Liu; Christina Thantrakul; Shu Kan; Connie Chang-Hasnain; Dong-Ru Ho
Journal:  IEEE J Transl Eng Health Med       Date:  2020-01-30       Impact factor: 3.316

Review 3.  Therapeutic drug monitoring of cyclosporin. Practical applications and limitations.

Authors:  V Rodighiero
Journal:  Clin Pharmacokinet       Date:  1989-01       Impact factor: 6.447

4.  A review on therapeutic drug monitoring of immunosuppressant drugs.

Authors:  Niloufar Mohammadpour; Sepideh Elyasi; Naser Vahdati; Amir Hooshang Mohammadpour; Jamal Shamsara
Journal:  Iran J Basic Med Sci       Date:  2011-11       Impact factor: 2.699
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.