Literature DB >> 3382542

Effect of the aggregation state of amphotericin B on its interaction with ergosterol.

I Gruda1, N Dussault.   

Abstract

The interaction of amphotericin B with ergosterol was studied in aqueous solutions of propanol. The mode of the interaction was found to be related to the aggregation state of amphotericin B. Ergosterol does not react (or reacts extremely slowly) with monomeric amphotericin B. Traces of a small aggregate, probably a dimer, enable a cooperative reaction. At high concentrations of the dimer, the reaction is immediate and the concentration of amphotericin B complexed with ergosterol is twice as high as the amount of added sterol. The interaction with ergosterol is hindered when the antibiotic is in micellar form. The pharmaceutical form, Fungizone, behaves similarly to the pure amphotericin B. Fungizone's greater solubility in water does not modify either the extent or the mode of interaction with ergosterol.

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Year:  1988        PMID： 3382542     DOI： 10.1139/o88-024

Source DB:  PubMed          Journal:  Biochem Cell Biol        ISSN： 0829-8211            Impact factor:   3.626


  12 in total

Review 1.  Amphotericin B: delivery systems.

Authors:  J Brajtburg; W G Powderly; G S Kobayashi; G Medoff
Journal:  Antimicrob Agents Chemother       Date:  1990-03       Impact factor: 5.191

2.  Encapsulation and release of Amphotericin B from an ABC triblock fluorous copolymer.

Authors:  Jun-Pil Jee; Aaron McCoy; Sandro Mecozzi
Journal:  Pharm Res       Date:  2011-07-08       Impact factor: 4.200

3.  Block copolymer micelles for the encapsulation and delivery of amphotericin B.

Authors:  Afsaneh Lavasanifar; John Samuel; Saeed Sattari; Glen S Kwon
Journal:  Pharm Res       Date:  2002-04       Impact factor: 4.200

4.  Structure-activity study of inhibition of amphotericin B (Fungizone) binding to sterols, toxicity to cells, and lethality to mice by esters of sucrose.

Authors:  I Gruda; D Milette; M Brother; G S Kobayashi; G Medoff; J Brajtburg
Journal:  Antimicrob Agents Chemother       Date:  1991-01       Impact factor: 5.191

5.  Serum pharmacology of amphotericin B applied in lipid emulsions.

Authors:  V Heinemann; B Kähny; U Jehn; D Mühlbayer; A Debus; K Wachholz; D Bosse; H J Kolb; W Wilmanns
Journal:  Antimicrob Agents Chemother       Date:  1997-04       Impact factor: 5.191

6.  Antifungal Efficacy of an Intravenous Formulation Containing Monomeric Amphotericin B, 5-Fluorocytosine, and Saline for Sodium Supplementation.

Authors:  Celeste Alvarez; David R Andes; Jeong Yeon Kang; Carmen Krug; Glen S Kwon
Journal:  Pharm Res       Date:  2017-02-15       Impact factor: 4.200

7.  Reformulation of Fungizone by PEG-DSPE Micelles: Deaggregation and Detoxification of Amphotericin B.

Authors:  Celeste Alvarez; Dae Hwan Shin; Glen S Kwon
Journal:  Pharm Res       Date:  2016-05-19       Impact factor: 4.200

8.  Ion channel behavior of amphotericin B in sterol-free and cholesterol- or ergosterol-containing supported phosphatidylcholine bilayer model membranes investigated by electrochemistry and spectroscopy.

Authors:  Weimin Huang; Zheling Zhang; Xiaojun Han; Jilin Tang; Jianguo Wang; Shaojun Dong; Erkang Wang
Journal:  Biophys J       Date:  2002-12       Impact factor: 4.033

9.  Effects of aggregation and solvent on the toxicity of amphotericin B to human erythrocytes.

Authors:  P Legrand; E A Romero; B E Cohen; J Bolard
Journal:  Antimicrob Agents Chemother       Date:  1992-11       Impact factor: 5.191

10.  Effects of the aggregation state of amphotericin B on its toxicity to mice.

Authors:  J Barwicz; S Christian; I Gruda
Journal:  Antimicrob Agents Chemother       Date:  1992-10       Impact factor: 5.191
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