Literature DB >> 3382181

Prolonged deterioration of ischemic brain energy metabolism and acidosis associated with hyperglycemia: human cerebral infarction studied by serial 31P NMR spectroscopy.

S R Levine1, K M Welch, J A Helpern, M Chopp, R Bruce, J Selwa, M B Smith.   

Abstract

We report on a patient with a large ischemic hemispherical stroke studied serially by 31P nuclear magnetic resonance spectroscopy. Persistent hyperglycemia was associated with prolonged acidosis in ischemic brain and failure of high-energy phosphate metabolism to recover. These in vivo human data support the concept that hyperglycemia adversely affects ischemic brain metabolism, pH, and clinical outcome.

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Year:  1988        PMID： 3382181     DOI： 10.1002/ana.410230423

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  9 in total

Review 1.  Clinical, radiological, and functional evaluation following acute stroke.

Authors:  D G Grosset
Journal:  Br J Clin Pharmacol       Date:  1992-12       Impact factor: 4.335

2.  Hypoglycemia prevents increase in lactic acidosis during reperfusion after temporary cerebral ischemia in rats.

Authors:  D Sappey-Marinier; L Chileuitt; M W Weiner; A I Faden; P R Weinstein
Journal:  NMR Biomed       Date:  1995-06       Impact factor: 4.044

3.  Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD+/Sirt1 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats.

Authors:  Qin Hu; Anatol Manaenko; Hetao Bian; Zongduo Guo; Jun-Long Huang; Zhen-Ni Guo; Peng Yang; Jiping Tang; John H Zhang
Journal:  Stroke       Date:  2017-05-11       Impact factor: 7.914

4.  Stress Hyperglycemia Does Not Affect Clinical Outcome of Diabetic Patients Receiving Intravenous Thrombolysis for Acute Ischemic Stroke.

Authors:  Giovanni Merlino; Sara Pez; Yan Tereshko; Gian Luigi Gigli; Simone Lorenzut; Andrea Surcinelli; Mariarosaria Valente
Journal:  Front Neurol       Date:  2022-06-13       Impact factor: 4.086

5.  Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide.

Authors:  Nicole Glaser; Natalie Yuen; Steven E Anderson; Daniel J Tancredi; Martha E O'Donnell
Journal:  Diabetes       Date:  2009-12-22       Impact factor: 9.461

6.  Investigation of stroke in sickle cell disease by 1H nuclear magnetic resonance spectroscopy.

Authors:  Z Wang; A R Bogdan; R A Zimmerman; D A Gusnard; J S Leigh; K Ohene-Frempong
Journal:  Neuroradiology       Date:  1992       Impact factor: 2.804

7.  Effects of Glycemic Gap on Post-Stroke Cognitive Impairment in Acute Ischemic Stroke Patients.

Authors:  Minwoo Lee; Jae-Sung Lim; Yerim Kim; Ju Hun Lee; Chul-Ho Kim; Sang-Hwa Lee; Min Uk Jang; Mi Sun Oh; Byung-Chul Lee; Kyung-Ho Yu
Journal:  Brain Sci       Date:  2021-05-11

8.  High glucose induces apoptosis and suppresses proliferation of adult rat neural stem cells following in vitro ischemia.

Authors:  Jian Chen; Yang Guo; Wei Cheng; Ruiqing Chen; Tianzhu Liu; Zhenzhou Chen; Sheng Tan
Journal:  BMC Neurosci       Date:  2013-03-04       Impact factor: 3.288

9.  LDH and PDH Activities in the Ischemic Brain and the Effect of Reperfusion-An Ex Vivo MR Study in Rat Brain Slices Using Hyperpolarized [1-13C]Pyruvate.

Authors:  Gal Sapir; David Shaul; Naama Lev-Cohain; Jacob Sosna; Moshe J Gomori; Rachel Katz-Brull
Journal:  Metabolites       Date:  2021-03-30
  9 in total

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