S Kumar1, R Raobiakady2, D Watkins3, M Terlizzo4, R H Bhogal5. 1. The Royal Marsden Hospital (NHS Foundation Trust), Department of Surgery, Fulham Road, Chelsea, London, SW3 6JJ, United Kingdom; Division of Radiotherapy & Imaging, The Institute for Cancer Research, 123 Old Brompton Road, London, United Kingdom; Imperial College London, Department of Surgery & Cancer, Exhibition Road, South Kensington, London, SW7 2BU, United Kingdom. 2. The Royal Marsden Hospital (NHS Foundation Trust), Department of Anaesthetics, Fulham Road, Chelsea, London, SW3 6JJ, United Kingdom. 3. The Royal Marsden Hospital (NHS Foundation Trust), Department of Oncology, Fulham Road, Chelsea, London, SW3 6JJ, United Kingdom. 4. The Royal Marsden Hospital (NHS Foundation Trust), Department of Histopathology, Fulham Road, Chelsea, London, SW3 6JJ, United Kingdom. 5. The Royal Marsden Hospital (NHS Foundation Trust), Department of Surgery, Fulham Road, Chelsea, London, SW3 6JJ, United Kingdom; Division of Radiotherapy & Imaging, The Institute for Cancer Research, 123 Old Brompton Road, London, United Kingdom. Electronic address: ricky.bhogal@uhb.nhs.uk.
Abstract
INTRODUCTION AND IMPORTANCE: There are limited reports in the literature of radical surgical resection for pancreatic neuroendocrine carcinoma (PNEC). In patients with non-functioning PNEC (NF-PNEC) within the tail of the pancreas tumours can cause splenic vein thrombosis (SVT) and subsequent sinitral portal hypertension (SPH). Radical surgical resection in such patients with concomitant liver metastasis has not previously been reported. CASE PRESENTATION: We present a 67-year old female patient who presented with a large NF-PNEC within the tail of the pancreas with liver metastasis. We performed a distal pancreatectomy, splenectomy, partial gastrectomy and liver resection to achieve radical resecton. DISCUSSION: All patients with NF-PNEC within the tail of the pancreatic should be considered for radical surgical resection. In the presence of multi-visceral involvement and complications such as SVT and/or SPH multi-speciality surgical expertise is likely to be required. CONCLUSION: Radical multi-visceral resection for large NF-PNEC can be safely performed in the presence of SVT and SPH.
INTRODUCTION AND IMPORTANCE: There are limited reports in the literature of radical surgical resection for pancreatic neuroendocrine carcinoma (PNEC). In patients with non-functioning PNEC (NF-PNEC) within the tail of the pancreas tumours can cause splenic vein thrombosis (SVT) and subsequent sinitral portal hypertension (SPH). Radical surgical resection in such patients with concomitant liver metastasis has not previously been reported. CASE PRESENTATION: We present a 67-year old female patient who presented with a large NF-PNEC within the tail of the pancreas with liver metastasis. We performed a distal pancreatectomy, splenectomy, partial gastrectomy and liver resection to achieve radical resecton. DISCUSSION: All patients with NF-PNEC within the tail of the pancreatic should be considered for radical surgical resection. In the presence of multi-visceral involvement and complications such as SVT and/or SPH multi-speciality surgical expertise is likely to be required. CONCLUSION: Radical multi-visceral resection for large NF-PNEC can be safely performed in the presence of SVT and SPH.