Rui Zhan1, Rongxing Qi2, Sheng Huang3, Yang Lu1, Xiaoyu Wang1, Jiashen Jiang1, Xiwu Ruan1, Anyi Song1. 1. Department of Radiology, The Second Affiliated Hospital of Nantong University, No 6 HaiErXiang (North) Road, Chongchuan District, Nantong city, 226001, Jiangsu Province, China. 2. Department of Radiology, The Second Affiliated Hospital of Nantong University, No 6 HaiErXiang (North) Road, Chongchuan District, Nantong city, 226001, Jiangsu Province, China. ntdocqirongxing@sina.com. 3. Department of Radiology, The Second Affiliated Hospital of Nantong University, No 6 HaiErXiang (North) Road, Chongchuan District, Nantong city, 226001, Jiangsu Province, China. z1317032070@163.com.
Abstract
PURPOSE: To determine the relationship between non-alcoholic fatty liver disease (NAFLD) evaluated by a hepatic fat fraction (HFF) using dual-energy computed tomography (DECT) and high-risk coronary plaques (HRP) in NAFLD patients. METHODS: We conducted a matched case-control study involving 172 NAFLD individuals recruited from August 2019 to September 2020. They underwent dual-energy coronary computed tomographic angiography and were classified as no-plaque, HRP negative and HRP positive groups. HFF values were measured using multimaterial decomposition algorithm of DECT, and the differences among three groups were compared. Multiple logistic regression analysis was performed to determine the independent correlation between HFF and HRP. Spearman rank correlation was used to assess the correlations between HFF and multiple variables. RESULTS: HRP positive group (15.3%) had higher HFF values than no-plaque (6.9%) and HRP negative groups (8.9%) (P < 0.001). After adjusting for confounding variables, the results indicated that HFF was an independent risk factor for HRP (OR 1.93, P < 0.001). Additionally, HFF significantly correlated with coronary artery calcium score, hepatic CT attenuation, epicardial and pericoronary adipose tissue volume, and CT attenuation (all P < 0.001). CONCLUSIONS: As a new imaging marker for the quantification of liver fat, HFF was independently associated with HRP.
PURPOSE: To determine the relationship between non-alcoholic fatty liver disease (NAFLD) evaluated by a hepatic fat fraction (HFF) using dual-energy computed tomography (DECT) and high-risk coronary plaques (HRP) in NAFLD patients. METHODS: We conducted a matched case-control study involving 172 NAFLD individuals recruited from August 2019 to September 2020. They underwent dual-energy coronary computed tomographic angiography and were classified as no-plaque, HRP negative and HRP positive groups. HFF values were measured using multimaterial decomposition algorithm of DECT, and the differences among three groups were compared. Multiple logistic regression analysis was performed to determine the independent correlation between HFF and HRP. Spearman rank correlation was used to assess the correlations between HFF and multiple variables. RESULTS: HRP positive group (15.3%) had higher HFF values than no-plaque (6.9%) and HRP negative groups (8.9%) (P < 0.001). After adjusting for confounding variables, the results indicated that HFF was an independent risk factor for HRP (OR 1.93, P < 0.001). Additionally, HFF significantly correlated with coronary artery calcium score, hepatic CT attenuation, epicardial and pericoronary adipose tissue volume, and CT attenuation (all P < 0.001). CONCLUSIONS: As a new imaging marker for the quantification of liver fat, HFF was independently associated with HRP.
Authors: Stefan B Puchner; Michael T Lu; Thomas Mayrhofer; Ting Liu; Amit Pursnani; Brian B Ghoshhajra; Quynh A Truong; Stephen D Wiviott; Jerome L Fleg; Udo Hoffmann; Maros Ferencik Journal: Radiology Date: 2014-11-04 Impact factor: 11.105
Authors: Stefan B Puchner; Ting Liu; Thomas Mayrhofer; Quynh A Truong; Hang Lee; Jerome L Fleg; John T Nagurney; James E Udelson; Udo Hoffmann; Maros Ferencik Journal: J Am Coll Cardiol Date: 2014-08-19 Impact factor: 24.094
Authors: Ian J Neeland; Robert Ross; Jean-Pierre Després; Yuji Matsuzawa; Shizuya Yamashita; Iris Shai; Jaap Seidell; Paolo Magni; Raul D Santos; Benoit Arsenault; Ada Cuevas; Frank B Hu; Bruce Griffin; Alberto Zambon; Philip Barter; Jean-Charles Fruchart; Robert H Eckel Journal: Lancet Diabetes Endocrinol Date: 2019-07-10 Impact factor: 32.069
Authors: Morteza Naghavi; Peter Libby; Erling Falk; S Ward Casscells; Silvio Litovsky; John Rumberger; Juan Jose Badimon; Christodoulos Stefanadis; Pedro Moreno; Gerard Pasterkamp; Zahi Fayad; Peter H Stone; Sergio Waxman; Paolo Raggi; Mohammad Madjid; Alireza Zarrabi; Allen Burke; Chun Yuan; Peter J Fitzgerald; David S Siscovick; Chris L de Korte; Masanori Aikawa; K E Juhani Airaksinen; Gerd Assmann; Christoph R Becker; James H Chesebro; Andrew Farb; Zorina S Galis; Chris Jackson; Ik-Kyung Jang; Wolfgang Koenig; Robert A Lodder; Keith March; Jasenka Demirovic; Mohamad Navab; Silvia G Priori; Mark D Rekhter; Raymond Bahr; Scott M Grundy; Roxana Mehran; Antonio Colombo; Eric Boerwinkle; Christie Ballantyne; William Insull; Robert S Schwartz; Robert Vogel; Patrick W Serruys; Goran K Hansson; David P Faxon; Sanjay Kaul; Helmut Drexler; Philip Greenland; James E Muller; Renu Virmani; Paul M Ridker; Douglas P Zipes; Prediman K Shah; James T Willerson Journal: Circulation Date: 2003-10-07 Impact factor: 29.690