Antonio Terracciano1, Damaris Aschwanden1, Yannick Stephan2, Antonio Cerasa3,4, Luca Passamonti5,6, Nicola Toschi7,8, Angelina R Sutin9. 1. Department of Geriatrics, Florida State University College of Medicine, Tallahassee, Florida, USA. 2. Euromov, University of Montpellier, Montpellier, France. 3. Institute for Biomedical Research and Innovation, National Research Council (IRIB-CNR), Mangone, Italy. 4. S. Anna Institute, Crotone, Italy. 5. Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom. 6. Istituto di Bioimmagini e Fisiologia Molecolare (IBFM), Consiglio Nazionale delle Ricerche (CNR), Milan, Italy. 7. Department of Biomedicine & Prevention, University "Tor Vergata", Rome, Italy. 8. A.A. Martinos Center for Biomedical Imaging - Harvard Medical School/MGH, Charlestown, Massachusetts, USA. 9. Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee, Florida, USA.
Abstract
BACKGROUND: Neuroticism is linked to mood disorders and Alzheimer's disease, but fewer studies have tested the prospective association with Parkinson's disease (PD). OBJECTIVES: To examine the association between neuroticism and risk of PD in a large cohort and a meta-analysis of prospective cohort studies. METHODS: Participants from the UK Biobank (N = 490,755) completed a neuroticism scale in 2006-2010. Incident PD was ascertained using electronic health records or death records up to 2018. The systematic search and meta-analysis followed the MOOSE guidelines. RESULTS: During 11.91 years of follow-up (mean = 8.88 years; 4,360,105 person-years) 1142 incident PD cases were identified. Neuroticism was associated with higher risk of incident PD, both as continuous (HR = 1.28; 95% CI: 1.21-1.36) and categorical variable (top vs. bottom quartiles: HR = 1.88; 95% CI: 1.60-2.22). The association remained significant after accounting for age, sex, smoking, physical activity, anxiety, and depressed mood, and after excluding cases that occurred within the first 5 years of follow-up. The associations were similar for women and men and across levels of socioeconomic status. Random-effect meta-analysis of four prospective studies (N = 548,284) found neuroticism associated with increased risk of incident PD (HR = 1.82; 95% CI: 1.59-2.08; P = 7.31-19 ). There was no evidence of heterogeneity across studies with follow-ups ranging from one to four decades. CONCLUSION: The results from the large UK Biobank and meta-analysis of prospective studies indicate that neuroticism is consistently associated with a higher risk of incident PD.
BACKGROUND: Neuroticism is linked to mood disorders and Alzheimer's disease, but fewer studies have tested the prospective association with Parkinson's disease (PD). OBJECTIVES: To examine the association between neuroticism and risk of PD in a large cohort and a meta-analysis of prospective cohort studies. METHODS:Participants from the UK Biobank (N = 490,755) completed a neuroticism scale in 2006-2010. Incident PD was ascertained using electronic health records or death records up to 2018. The systematic search and meta-analysis followed the MOOSE guidelines. RESULTS: During 11.91 years of follow-up (mean = 8.88 years; 4,360,105 person-years) 1142 incident PD cases were identified. Neuroticism was associated with higher risk of incident PD, both as continuous (HR = 1.28; 95% CI: 1.21-1.36) and categorical variable (top vs. bottom quartiles: HR = 1.88; 95% CI: 1.60-2.22). The association remained significant after accounting for age, sex, smoking, physical activity, anxiety, and depressed mood, and after excluding cases that occurred within the first 5 years of follow-up. The associations were similar for women and men and across levels of socioeconomic status. Random-effect meta-analysis of four prospective studies (N = 548,284) found neuroticism associated with increased risk of incident PD (HR = 1.82; 95% CI: 1.59-2.08; P = 7.31-19 ). There was no evidence of heterogeneity across studies with follow-ups ranging from one to four decades. CONCLUSION: The results from the large UK Biobank and meta-analysis of prospective studies indicate that neuroticism is consistently associated with a higher risk of incident PD.
Authors: Li Zhou; Steven W H Chau; Yaping Liu; Jing Wang; Jihui Zhang; Ngan Yin Chan; Joey W Y Chan; Bei Huang; Sijing Chen; Shirley Xin Li; Vincent Chung Tong Mok; Yun Kwok Wing Journal: NPJ Parkinsons Dis Date: 2022-07-14