Ping Zhou1, Qiong Xiao2, Lan Chen1, Zhi-Jie Zou1, Yu-Qing Wang1, Lin Zhu1, Hai-Yan Yu1, Cheng-Guang Zhao3, Yu-Bin Wu3, Xuan-Yi Du4. 1. Department of pediatrics, 2nd Affiliated Hospital of Harbin Medical University,Harbin, Heilongjiang province, 150086,China. 2. Department of Infections Diseases, Children's Hospital of Harbin,Harbin city, Heilongjiang province, 150010,China. 3. Pediatric kidney rheumatology, Shengjing Hospital Affiliated of China Medical University, Shenyang, 110004, China. 4. Department of Nephrology, 2nd Affiliated Hospital of Harbin Medical University, No.246 of Xuefu street, Nangang District, Harbin, 150086, China.
Abstract
OBJECTIVE: This study aims to observe the curative effect of Huaiqihuang Granules adjuvant therapy on primary nephrotic syndrome (PNS). METHODS: A total of 112 children with PNS were randomly divided into three groups, and changes in serum inflammatory cytokines, interleukin, lymphocyte subsets and immunoglobulin were observed. RESULTS: Before treatment, IL-18, TNF-α, CD8+ increased, while IL-10, CD4+, NK cells, IgA, IgG and Foxp3+Treg cells decreased. After Huaiqihuang Granules treatment, IL-18, TNF-α, CD8+ decreased, while IL-10, CD4+, NK cells, IgA, IgG and Foxp3+Treg cells increased. CONCLUSION: Functions of cell immunity and humoral immunity in PNS patients before treatment were suppressed and disordered. Huaiqihuang granules can play a role in immunoregulation, with slight side reactions.
OBJECTIVE: This study aims to observe the curative effect of Huaiqihuang Granules adjuvant therapy on primary nephrotic syndrome (PNS). METHODS: A total of 112 children with PNS were randomly divided into three groups, and changes in serum inflammatory cytokines, interleukin, lymphocyte subsets and immunoglobulin were observed. RESULTS: Before treatment, IL-18, TNF-α, CD8+ increased, while IL-10, CD4+, NK cells, IgA, IgG and Foxp3+Treg cells decreased. After Huaiqihuang Granules treatment, IL-18, TNF-α, CD8+ decreased, while IL-10, CD4+, NK cells, IgA, IgG and Foxp3+Treg cells increased. CONCLUSION: Functions of cell immunity and humoral immunity in PNS patients before treatment were suppressed and disordered. Huaiqihuang granules can play a role in immunoregulation, with slight side reactions.
Authors: Fehime Kara Eroglu; Diclehan Orhan; Mihriban İnözü; Ali Duzova; Bora Gulhan; Fatih Ozaltin; Rezan Topaloglu Journal: Pediatr Int Date: 2019-12-02 Impact factor: 1.524
Authors: Hai-Yun Geng; Li Cao; Wei Wang; Da-Kun Chen; Chao-Ying Chen; Mei Chu; Li-Na Ji; Jing-Jing Wang; Juan Tu; Jian-Guo Li; Hua-Rong Li; Pei-Wei Du Journal: Zhongguo Dang Dai Er Ke Za Zhi Date: 2015-01
Authors: Manuela Colucci; Rita Carsetti; Jessica Serafinelli; Salvatore Rocca; Laura Massella; Antonio Gargiulo; Anna Lo Russo; Claudia Capponi; Nicola Cotugno; Ottavia Porzio; Andrea Onetti Muda; Paolo Palma; Francesco Emma; Marina Vivarelli Journal: Front Immunol Date: 2019-07-16 Impact factor: 7.561