Sepideh Darougar1, Mahboubeh Mansouri2, Solmaz Hassani3, Mohammad Reza Sohrabi4,5, Paniz Hashemitari6. 1. Department of Pediatrics, Tehran Medical Sciences Branch, Islamic Azad University Tehran, Iran. 2. Department of Allergy and Clinical Immunology, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences Tehran, Iran. 3. Mofid Children Hospital, Shahid Beheshti University of Medical Sciences Tehran, Iran. 4. Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences Tehran, Iran. 5. Community Medicine Department, School of Medicine, Shahid Beheshti University of Medical Sciences Tehran, Iran. 6. Humanitas University Milan, Italy.
Abstract
BACKGROUND: Food allergy which usually develops in the first year of life is a risk factor for persistent asthma in young children. Cow's milk has been demonstrated to be the most commonly identified food allergen in children. Considering the central role of non-IgE-mediated food allergies in the development of hidden gastroesophageal reflux and consequently asthma, we evaluated the effect of eliminating food allergens to better control asthma. METHOD: A total of eighty infants and children up to the age of 12 referred to the Asthma Clinic of Mofid Children Hospital for a period of one year were enrolled in this study. In those patients whose asthma remained uncontrolled (Childhood Asthma Control Test ≤19) despite a 2-week period of treatment, we advocated a 2-week-diet based on eliminating cow's milk in conjunction with asthma conventional therapy. For breast-fed infants, mothers were requested to eliminate these products from their daily intake regimens and for formula-fed infants, the elemental based formula was started. RESULTS: Three of the patients were lost in follow-up and six of them were excluded from the study because of non-compliance. The Asthma Control Test score which was less than or equal to 19 in the entire study population, increased to 20 or more after we began a diet based on the elimination of cow's milk in all but 13 participants. CONCLUSION: To conclude, the results were promising, demonstrating that a cow's milk protein elimination diet is a prudent approach in the management of patients with recalcitrant asthma, and can be considered as the missing link in asthma treatment. AJCEI
BACKGROUND: Food allergy which usually develops in the first year of life is a risk factor for persistent asthma in young children. Cow's milk has been demonstrated to be the most commonly identified food allergen in children. Considering the central role of non-IgE-mediated food allergies in the development of hidden gastroesophageal reflux and consequently asthma, we evaluated the effect of eliminating food allergens to better control asthma. METHOD: A total of eighty infants and children up to the age of 12 referred to the Asthma Clinic of Mofid Children Hospital for a period of one year were enrolled in this study. In those patients whose asthma remained uncontrolled (Childhood Asthma Control Test ≤19) despite a 2-week period of treatment, we advocated a 2-week-diet based on eliminating cow's milk in conjunction with asthma conventional therapy. For breast-fed infants, mothers were requested to eliminate these products from their daily intake regimens and for formula-fed infants, the elemental based formula was started. RESULTS: Three of the patients were lost in follow-up and six of them were excluded from the study because of non-compliance. The Asthma Control Test score which was less than or equal to 19 in the entire study population, increased to 20 or more after we began a diet based on the elimination of cow's milk in all but 13 participants. CONCLUSION: To conclude, the results were promising, demonstrating that a cow's milk protein elimination diet is a prudent approach in the management of patients with recalcitrant asthma, and can be considered as the missing link in asthma treatment. AJCEI
Authors: Alan M Leichtner; Lynette A Gillis; Sandeep Gupta; James Heubi; Marsha Kay; Michael R Narkewicz; Elizabeth A Rider; Paul A Rufo; Thomas J Sferra; Jonathan Teitelbaum Journal: J Pediatr Gastroenterol Nutr Date: 2013-01 Impact factor: 2.839
Authors: Tiphaine Bihouée; Gregory Bouchaud; Julie Chesné; David Lair; Camille Rolland-Debord; Faouzi Braza; Marie-Aude Cheminant; Philippe Aubert; Guillaume Mahay; Christine Sagan; Michel Neunlist; Sophie Brouard; Marie Bodinier; Antoine Magnan Journal: Respir Res Date: 2014-11-30