| Literature DB >> 33813355 |
Eric Farfour1, Anne-Gaëlle Si Larbi2, Vincent Cattoir3, Stéphane Corvec4, Thomas Guillard5, Antoine Grillon6, Christophe Isnard7, Audrey Mérens8, Nicolas Degand9, Typhaine Billard-Pomares10, Damien Fournier11, Emmanuelle Bille12, Cécile Le Brun13, Chloé Plouzeau14, Emilie Flevin15, Nicolas Yin16, Paul-Louis Woerther17, Julie Lourtet18, Philippe Lesprit2, Alban Le Monnier18.
Abstract
Temocillin is used for several years in some European countries but, only since 2015 in France. We assessed the susceptibility of Enterobacterales strains isolated from blood culture 1 year before (2014) and 2 years after (2017) its use in France. 1,387 strains were included by 17 clinical laboratories located throughout France: 363 in 2014 and 1,024 in 2017. The rate of resistance to temocillin was 4.6% and 26.7% in 3rd generation cephalosporin (3GC) susceptible and resistant strains respectively. Cephalosporinase-overproducer (COPE) strains were significantly more resistant to temocillin (37.7%) than ESBL-producer (ESBL-PE) (23.5%) (P < 0.01). The rate of temocillin resistance was correlated to the number of inactive beta-lactams. The rate of resistance to temocillin trend to increase from 13.9% in 2014 to 23.9% in 2017 (P < 0.01). Temocillin remains highly active against Enterobacterales but the trend in resistance should be assessed over time.Entities:
Keywords: Antibiotic resistance; Cephalosporinase-overproducing strain (COPE); Extended-spectrum beta-lactamases (ESBL); Temocillin; Third-generation cephalosporin (3GC)
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Year: 2021 PMID： 33813355 DOI： 10.1016/j.diagmicrobio.2021.115368
Source DB: PubMed Journal: Diagn Microbiol Infect Dis ISSN： 0732-8893 Impact factor: 2.803