Literature DB >> 33813026

Tryptophan metabolism in brain tumors - IDO and beyond.

Michael Platten1, Mirco Friedrich2, Derek A Wainwright3, Verena Panitz4, Christiane A Opitz5.   

Abstract

Metabolism of the essential amino acid tryptophan is a key metabolic pathway that restricts antitumor immunity and is a drug development target for cancer immunotherapy. Tryptophan metabolism is active in brain tumors including gliomas and promotes a malignant phenotype and contributes to the immunosuppressive tumor microenvironment. In recent years, improved understanding of the regulation and downstream function of tryptophan metabolism has been significantly expanded beyond the initial in vitro observation that the enzyme indoleamine-2,3-dioxygenase 1 (IDO1) promotes the depletion of intracellular tryptophan. Here, we revisit the specific roles of tryptophan metabolites in regulating brain functioning and neuronal integrity as well as in the context of brain tumors. This review summarizes recent developments in identifying key regulators, as well as the cellular and molecular effects of tryptophan metabolism with a particular focus on potential therapeutic targets in glioma.
Copyright © 2021 Elsevier Ltd. All rights reserved.

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Year:  2021        PMID： 33813026      PMCID： PMC8373719          DOI： 10.1016/j.coi.2021.03.005

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  80 in total

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Journal:  Nature       Date:  2020-12-16       Impact factor: 49.962

3.  Tryptophan-2,3-dioxygenase is regulated by prostaglandin E2 in malignant glioma via a positive signaling loop involving prostaglandin E receptor-4.

Authors:  Katharina Ochs; Martina Ott; Katharina J Rauschenbach; Katrin Deumelandt; Felix Sahm; Christiane A Opitz; Andreas von Deimling; Wolfgang Wick; Michael Platten
Journal:  J Neurochem       Date:  2016-01-22       Impact factor: 5.372

4.  Targeting NAD+ Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance.

Authors:  Esther P Jane; Daniel R Premkumar; Swetha Thambireddy; Brian Golbourn; Sameer Agnihotri; Kelsey C Bertrand; Stephen C Mack; Max I Myers; Ansuman Chattopadhyay; D Lansing Taylor; Mark E Schurdak; Andrew M Stern; Ian F Pollack
Journal:  Mol Cancer Res       Date:  2020-04-01       Impact factor: 5.852

5.  IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma.

Authors:  Erik Ladomersky; Lijie Zhai; Alicia Lenzen; Kristen L Lauing; Jun Qian; Denise M Scholtens; Galina Gritsina; Xuebing Sun; Ye Liu; Fenglong Yu; Wenfeng Gong; Yong Liu; Beibei Jiang; Tristin Tang; Ricky Patel; Leonidas C Platanias; C David James; Roger Stupp; Rimas V Lukas; David C Binder; Derek A Wainwright
Journal:  Clin Cancer Res       Date:  2018-03-02       Impact factor: 12.531

6.  Imaging tryptophan uptake with positron emission tomography in glioblastoma patients treated with indoximod.

Authors:  Rimas V Lukas; Csaba Juhász; Derek A Wainwright; Charles David James; Eugene Kennedy; Roger Stupp; Maciej S Lesniak
Journal:  J Neurooncol       Date:  2018-11-10       Impact factor: 4.130

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Review 8.  Targeting CD73 to augment cancer immunotherapy.

Authors:  Meejeon Roh; Derek A Wainwright; Jennifer D Wu; Yong Wan; Bin Zhang
Journal:  Curr Opin Pharmacol       Date:  2020-08-07       Impact factor: 5.547

9.  Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production.

Authors:  Margaret M Lowe; Jeff E Mold; Bittoo Kanwar; Yong Huang; Alexander Louie; Michael P Pollastri; Cuihua Wang; Gautam Patel; Diana G Franks; Jennifer Schlezinger; David H Sherr; Allen E Silverstone; Mark E Hahn; Joseph M McCune
Journal:  PLoS One       Date:  2014-02-03       Impact factor: 3.240

Review 10.  From Suppressor T cells to Regulatory T cells: How the Journey That Began with the Discovery of the Toxic Effects of TCDD Led to Better Understanding of the Role of AhR in Immunoregulation.

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Journal:  Int J Mol Sci       Date:  2020-10-22       Impact factor: 5.923
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  5 in total

1.  Novel Substituted Tetrahydroquinoline Compounds as Indoleamine-2,3-dioxygenase (IDO) Inhibitors.

Authors:  Ram W Sabnis
Journal:  ACS Med Chem Lett       Date:  2021-09-14       Impact factor: 4.632

2.  Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma.

Authors:  Verena Panitz; Saša Končarević; Ahmed Sadik; Dennis Friedel; Tobias Bausbacher; Saskia Trump; Vadim Farztdinov; Sandra Schulz; Philipp Sievers; Stefan Schmidt; Ina Jürgenson; Stephan Jung; Karsten Kuhn; Irada Pflüger; Suraj Sharma; Antje Wick; Pauline Pfänder; Stefan Selzer; Philipp Vollmuth; Felix Sahm; Andreas von Deimling; Ines Heiland; Carsten Hopf; Peter Schulz-Knappe; Ian Pike; Michael Platten; Wolfgang Wick; Christiane A Opitz
Journal:  Theranostics       Date:  2021-09-03       Impact factor: 11.556

3.  Indolethylamine-N-Methyltransferase Inhibits Proliferation and Promotes Apoptosis of Human Prostate Cancer Cells: A Mechanistic Exploration.

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Journal:  Front Immunol       Date:  2022-08-25       Impact factor: 8.786

Review 5.  Glioblastoma: Relationship between Metabolism and Immunosuppressive Microenvironment.

Authors:  Ainhoa Hernández; Marta Domènech; Ana M Muñoz-Mármol; Cristina Carrato; Carmen Balana
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  5 in total

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