Wanying Bao1, Ya Li1, Tao Wang1, Xiaoou Li1, Junyun He2, Yashu Wang3, Fuqiang Wen4, Jun Chen5. 1. Division of Pulmonary Diseases, State Key Laboratory of Biotherapy, And Department of Respiratory and Critical Care Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, 610041, China. 2. Department of Respiratory Medicine, Hospital of Chengdu office of People's Government of Tibetan Autonomous Region of China, Chengdu, Sichuan, 610041, China. 3. Department of Clinical Laboratory, Xinjiang Provincial Corps Hospital Chinese People's Armed Police Forces, Urumqi, Xinjiang, 830091, China. 4. Division of Pulmonary Diseases, State Key Laboratory of Biotherapy, And Department of Respiratory and Critical Care Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, 610041, China. Electronic address: wenfuqiang@scu.edu.cn. 5. Division of Pulmonary Diseases, State Key Laboratory of Biotherapy, And Department of Respiratory and Critical Care Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, 610041, China. Electronic address: junchen@scu.edu.cn.
Abstract
PURPOSE: Influenza is a threat to patients with chronic obstructive pulmonary disease (COPD), influenza vaccination help to reduce incidence of influenza infection, however, whether it is beneficial to COPD patients in clinical outcomes lacks for evidence due to limited studies and participations. METHODS: We searched PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI) and China Science and Technology Journal Database (CSTJ) to retrieve eligible studies regardless of study design published before August 2020, and conducted meta-analysis with odds ratio (OR) and mean difference (MD). The quality of included studies and pooled evidences were assessed. Narrative summaries were provided where data were insufficient for meta-analysis. RESULTS: 2831 COPD patients were included, the pooled results showed that influenza vaccination reduced the exacerbations (P = 0.0001) and trends of hospitalizations (P = 0.09) in COPD patients. Further subgroup analysis showed that the reduction of exacerbations and hospitalizations were significant in patients with FEV1<50 % predicted (P = 0.01 and P < 0.0001 respectively), but not in those with FEV1≥50 % predicted (P = 0.23 and P = 0.76 respectively). No significant effect of influenza vaccination on all-cause mortality was observed. CONCLUSIONS: Our findings support a protective role of influenza vaccination in COPD patients, a yearly influenza vaccination should be strongly recommended for all COPD patients, especially those with severe airflow limitation, to reduce possible influenza infection, and thus associated exacerbations and hospitalizations.
PURPOSE: Influenza is a threat to patients with chronic obstructive pulmonary disease (COPD), influenza vaccination help to reduce incidence of influenza infection, however, whether it is beneficial to COPDpatients in clinical outcomes lacks for evidence due to limited studies and participations. METHODS: We searched PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI) and China Science and Technology Journal Database (CSTJ) to retrieve eligible studies regardless of study design published before August 2020, and conducted meta-analysis with odds ratio (OR) and mean difference (MD). The quality of included studies and pooled evidences were assessed. Narrative summaries were provided where data were insufficient for meta-analysis. RESULTS: 2831 COPDpatients were included, the pooled results showed that influenza vaccination reduced the exacerbations (P = 0.0001) and trends of hospitalizations (P = 0.09) in COPDpatients. Further subgroup analysis showed that the reduction of exacerbations and hospitalizations were significant in patients with FEV1<50 % predicted (P = 0.01 and P < 0.0001 respectively), but not in those with FEV1≥50 % predicted (P = 0.23 and P = 0.76 respectively). No significant effect of influenza vaccination on all-cause mortality was observed. CONCLUSIONS: Our findings support a protective role of influenza vaccination in COPDpatients, a yearly influenza vaccination should be strongly recommended for all COPDpatients, especially those with severe airflow limitation, to reduce possible influenza infection, and thus associated exacerbations and hospitalizations.
Authors: Pavo Marijic; Larissa Schwarzkopf; Werner Maier; Franziska Trudzinski; Lars Schwettmann; Michael Kreuter Journal: Ann Am Thorac Soc Date: 2022-09