Rongjing Song1, Xuecheng Zhao2, Da-Qi Zhang3, Rong Wang4, Yufei Feng5. 1. Department of Pharmacy, Peking University People's Hospital, Beijing 100044, China. 2. Department of Emergency Medicine, China-Japan Friendship Hospital, Beijing 100029, China. Electronic address: zhaoxuecheng1@sina.com. 3. Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou 570102, China. 4. Key Laboratory of Tropical Biological Resources of Ministry of Education, Department of Pharmaceutical Sciences, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China. 5. Department of Pharmacy, Peking University People's Hospital, Beijing 100044, China. Electronic address: yufeifeng21@sina.com.
Abstract
AIMS: This study aimed to provide evidence on the levels of circulating irisin in patients with type 2 diabetes mellitus (T2DM). METHODS: A meta-analysis was conducted to compare the irisin levels in patients with T2DM with the levels in control patients. PubMed, Embase, CENTRAL databases, and other sources were searched from inception through September 2020. Review manager software version 5.4 was used to calculate the pooled outcomes. Heterogeneity was measured using I2 statistics. RESULTS: Twenty-six studies involving 3667 participants met the inclusion criteria and were analyzed in this study. We found that irisin levels were significantly lower in patients with T2DM [Standard (Std.) Mean Difference, -1.02; 95% confidence interval (95% CI), -1.37 to -0.67; p < 0.00001]. Sensitivity analysis confirmed the robustness of this result (Std. Mean Difference, -0.56; 95% CI, -0.73 to -0.39; p < 0.00001). CONCLUSIONS: As compared to the control group and irrespective of differences in ethnicities, age groups, study designs, blood samples, sample sizes, language used for the study, or ELISA kits, lower levels of irisin were observed in patients with T2DM.
AIMS: This study aimed to provide evidence on the levels of circulating irisin in patients with type 2 diabetes mellitus (T2DM). METHODS: A meta-analysis was conducted to compare the irisin levels in patients with T2DM with the levels in control patients. PubMed, Embase, CENTRAL databases, and other sources were searched from inception through September 2020. Review manager software version 5.4 was used to calculate the pooled outcomes. Heterogeneity was measured using I2 statistics. RESULTS: Twenty-six studies involving 3667 participants met the inclusion criteria and were analyzed in this study. We found that irisin levels were significantly lower in patients with T2DM [Standard (Std.) Mean Difference, -1.02; 95% confidence interval (95% CI), -1.37 to -0.67; p < 0.00001]. Sensitivity analysis confirmed the robustness of this result (Std. Mean Difference, -0.56; 95% CI, -0.73 to -0.39; p < 0.00001). CONCLUSIONS: As compared to the control group and irrespective of differences in ethnicities, age groups, study designs, blood samples, sample sizes, language used for the study, or ELISA kits, lower levels of irisin were observed in patients with T2DM.