Literature DB >> 33809576

Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms.

Valéria L Carvalho1,2, Maureen T Long1.   

Abstract

Arthropod-borne viruses (arboviruses) are global pathogens circulating endemically with local explosive outbreaks and constant encroachment into new locations. Few vaccines against arboviruses exist; most for humans are in development or clinical trials. Insect-specific viruses (ISVs) offer a unique platform for expression of arbovirus proteins, through the creation of ISV/arbovirus chimeras. Studies have shown promising results of these vaccines with several advantages over their wild-type counterparts. In this review, we discuss the current status of these potential vaccines using ISVs.

Entities:  

Keywords:  arbovirus; insect-specific virus; vaccines

Year:  2021        PMID： 33809576      PMCID： PMC7999276          DOI： 10.3390/vaccines9030263

Source DB:  PubMed          Journal:  Vaccines (Basel)        ISSN： 2076-393X


  30 in total

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