Literature DB >> 3380500

Antibiotic concentration in maternal blood, cord blood, and placental membranes in chorioamnionitis.

L C Gilstrap1, R E Bawdon, J Burris.   

Abstract

Levels of five antibiotics used in treating chorioamnionitis were measured in maternal and cord blood and placenta. Ampicillin provided the highest ratio of cord to maternal blood (0.71). Gentamicin was also relatively high in this respect and also had the highest placenta to maternal blood ratio (3.97). Based on these findings, the commonly used combination of ampicillin and gentamicin seems appropriate, although additional anaerobic coverage may be needed.

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Year:  1988        PMID: 3380500

Source DB:  PubMed          Journal:  Obstet Gynecol        ISSN: 0029-7844            Impact factor:   7.661


  4 in total

1.  First trimester exposure to cefuroxime: a prospective cohort study.

Authors:  M Berkovitch; I Segal-Socher; R Greenberg; M Bulkowshtein; J Arnon; P Merlob; A Or-Noy
Journal:  Br J Clin Pharmacol       Date:  2000-08       Impact factor: 4.335

2.  Transplacental passage of clindamycin from mother to neonate.

Authors:  C D Wear; C V Towers; M S Brown; B Weitz; S Porter; L Wolfe
Journal:  J Perinatol       Date:  2016-08-04       Impact factor: 2.521

3.  The Role of Megalin in the Transport of Gentamicin Across BeWo Cells, an In Vitro Model of the Human Placenta.

Authors:  Amal A Akour; Mary Jayne Kennedy; Phillip M Gerk
Journal:  AAPS J       Date:  2015-05-19       Impact factor: 4.009

4.  Modern management of clinical chorioamnionitis.

Authors:  T Westover; R A Knuppel
Journal:  Infect Dis Obstet Gynecol       Date:  1995
  4 in total

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