Biagio Rapone1, Elisabetta Ferrara2, Massimo Corsalini3, Erda Qorri4, Ilaria Converti5, Felice Lorusso6, Maurizio Delvecchio7, Antonio Gnoni1, Salvatore Scacco1, Antonio Scarano6. 1. Department of Basic Medical Sciences, Neurosciences and Sense Organs, "Aldo Moro" University of Bari, 70121 Bari, Italy. 2. Complex Operative Unit of Odontostomatology, Hospital S.S. Annunziata, 66100 Chieti, Italy. 3. Interdisciplinary Department of Medicine, University of Bari, 70121 Bari, Italy. 4. Dean Faculty of Medical Sciences, Albanian University, Bulevardi Zogu I, 1001 Tirana, Albania. 5. Department of Emergency and Organ Transplantation, Division of Plastic and Reconstructive Surgery, "Aldo Moro" University of Bari, 70121 Bari, Italy. 6. Department of Oral Science, Nano and Biotechnology and CeSi-Met University of Chieti-Pescara, 66100 Chieti, Italy. 7. Department of Metabolic and Genetic Diseases, Giovanni XXIII Children's Hospital, 70126 Bari, Italy.
Abstract
BACKGROUND: Based on the holistic approach to prevention diabetic disease, the role of periodontal inflammation in type 2 diabetes mellitus (T2DM) is under intensive scrutiny. Data from clinical trials have shown benefit from a periodontal therapy in providing patients with type 2 diabetes improvement despite relatively disappointing long-terms response rates. The aim of this study was to investigate the short-term glycemic control level and systemic inflammatory status after periodontal therapy. METHODS: This was a randomized trial with a 6-months follow-up. Participants aged 56.4 ± 7.9 years with diagnosed type 2 diabetes and periodontitis were enrolled. Among the 187 type 2 diabetic patients, 93 were randomly assigned to receive non-surgical periodontal treatment immediately and 94 to receive the delayed treatment. Within and between groups comparison was done during the study period, and the differences between groups were assessed. RESULTS: The difference between HbA1c values at baseline (Mdn = 7.7) and 6 months after non-surgical periodontal treatment (Mdn = 7.2) was statistically significant, U = 3174.5, p = 0.012, r = 0.187. However, although technically a positive correlation, the relationship between the glycated hemoglobin value and periodontal variables was weak. The differences between both the groups over 6 months were not statistically considerable, failing to reach statistical significance. At 6 months the difference between groups about the C-reactive protein (CRP) levels was statistically significant, U=1839.5, p = 0, r = 0.472, with a lower concentration for the intervention group. Furthermore, the intervention group showed a statistically significant difference between baseline and 6 months evaluation (U = 2606.5, p = 0, r = 0.308). CONCLUSIONS: The periodontal intervention potentially may allow individuals with type 2 diabetes to improve glycemic control and CRP concentrations, and diabetes alters the periodontal status.
RCT Entities:
BACKGROUND: Based on the holistic approach to prevention diabetic disease, the role of periodontal inflammation in type 2 diabetes mellitus (T2DM) is under intensive scrutiny. Data from clinical trials have shown benefit from a periodontal therapy in providing patients with type 2 diabetes improvement despite relatively disappointing long-terms response rates. The aim of this study was to investigate the short-term glycemic control level and systemic inflammatory status after periodontal therapy. METHODS: This was a randomized trial with a 6-months follow-up. Participants aged 56.4 ± 7.9 years with diagnosed type 2 diabetes and periodontitis were enrolled. Among the 187 type 2 diabeticpatients, 93 were randomly assigned to receive non-surgical periodontal treatment immediately and 94 to receive the delayed treatment. Within and between groups comparison was done during the study period, and the differences between groups were assessed. RESULTS: The difference between HbA1c values at baseline (Mdn = 7.7) and 6 months after non-surgical periodontal treatment (Mdn = 7.2) was statistically significant, U = 3174.5, p = 0.012, r = 0.187. However, although technically a positive correlation, the relationship between the glycated hemoglobin value and periodontal variables was weak. The differences between both the groups over 6 months were not statistically considerable, failing to reach statistical significance. At 6 months the difference between groups about the C-reactive protein (CRP) levels was statistically significant, U=1839.5, p = 0, r = 0.472, with a lower concentration for the intervention group. Furthermore, the intervention group showed a statistically significant difference between baseline and 6 months evaluation (U = 2606.5, p = 0, r = 0.308). CONCLUSIONS: The periodontal intervention potentially may allow individuals with type 2 diabetes to improve glycemic control and CRP concentrations, and diabetes alters the periodontal status.
Entities:
Keywords:
C-reactive protein; dental public health; non-surgical periodontal treatment; periodontal inflammation; periodontitis; systemic inflammation; type 2 diabetes
Authors: Biagio Rapone; Elisabetta Ferrara; Luigi Santacroce; Skender Topi; Ilaria Converti; Antonio Gnoni; Antonio Scarano; Salvatore Scacco Journal: Int J Environ Res Public Health Date: 2020-10-09 Impact factor: 3.390
Authors: Terry C Simpson; Janet E Clarkson; Helen V Worthington; Laura MacDonald; Jo C Weldon; Ian Needleman; Zipporah Iheozor-Ejiofor; Sarah H Wild; Ambrina Qureshi; Andrew Walker; Veena A Patel; Dwayne Boyers; Joshua Twigg Journal: Cochrane Database Syst Rev Date: 2022-04-14