Literature DB >> 3380359

Oxygen free radical involvement in ischemia and reperfusion injury to brain.

W Cao1, J M Carney, A Duchon, R A Floyd, M Chevion.   

Abstract

Evidence is presented which implicates increased oxygen free radicals during ischemia reperfusion of gerbil brain. Salicylate, which reacts with hydroxyl free radicals to yield dihydroxybenzoic acid (DHBA), was used as an in vivo trap. Brain ischemia for at least 5 min followed by reperfusion yielded significantly increased brain DHBA. Without reperfusion or with only 2 min of ischemia and then reperfusion, the production of DHBA was not increased. Increased levels of DHBA in brain correlated with ischemia reperfusion-mediated behavioral modification of gerbils, but salicylate administration did not protect against the behavior changes.

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Year:  1988        PMID： 3380359     DOI： 10.1016/0304-3940(88)90132-2

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  59 in total

1.  Exacerbated responses to oxidative stress by an Na(+) load in isolated nerve terminals: the role of ATP depletion and rise of [Ca(2+)](i).

Authors:  C Chinopoulos; L Tretter; A Rozsa; V Adam-Vizi
Journal:  J Neurosci       Date:  2000-03-15       Impact factor: 6.167

Review 2.  Oxygen free radicals, inflammation, and synovitis: and synovitis: the current status.

Authors:  P Merry; P G Winyard; C J Morris; M Grootveld; D R Blake
Journal:  Ann Rheum Dis       Date:  1989-10       Impact factor: 19.103

3.  Protection against oxidative damage to CNS by alpha-phenyl-tert-butyl nitrone (PBN) and other spin-trapping agents: a novel series of nonlipid free radical scavengers.

Authors:  J M Carney; R A Floyd
Journal:  J Mol Neurosci       Date:  1991       Impact factor: 3.444

4.  Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

Authors:  J M Carney; P E Starke-Reed; C N Oliver; R W Landum; M S Cheng; J F Wu; R A Floyd
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-01       Impact factor: 11.205

5.  Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant.

Authors:  L I Bruijn; M F Beal; M W Becher; J B Schulz; P C Wong; D L Price; D W Cleveland
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-08       Impact factor: 11.205

Review 6.  Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress.

Authors:  Laszlo Tretter; Vera Adam-Vizi
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2005-12-29       Impact factor: 6.237

7.  Gene delivery of antioxidant enzymes inhibits human immunodeficiency virus type 1 gp120-induced expression of caspases.

Authors:  J-P Louboutin; L Agrawal; B A S Reyes; E J van Bockstaele; D S Strayer
Journal:  Neuroscience       Date:  2012-04-21       Impact factor: 3.590

8.  Nutritional prevention on hypertension, cerebral hemodynamics and thrombosis in stroke-prone spontaneously hypertensive rats.

Authors:  Takanori Noguchi; Katsumi Ikeda; Yasuto Sasaki; Yukio Yamori
Journal:  Cell Mol Neurobiol       Date:  2004-10       Impact factor: 5.046

9.  Protective effect of diphenyl diselenide on ischemia and reperfusion-induced cerebral injury: involvement of oxidative stress and pro-inflammatory cytokines.

Authors:  César A Brüning; Marina Prigol; Cristiane Luchese; Cristiano R Jesse; Marta M M F Duarte; Silvane S Roman; Cristina W Nogueira
Journal:  Neurochem Res       Date:  2012-07-31       Impact factor: 3.996

10.  Induction of nitric oxide synthase and microglial responses precede selective cell death induced by chronic impairment of oxidative metabolism.

Authors:  N Y Calingasan; L C Park; L L Calo; R R Trifiletti; S E Gandy; G E Gibson
Journal:  Am J Pathol       Date:  1998-08       Impact factor: 4.307
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