Literature DB >> 33800376

Haptoglobin and Its Related Protein, Zonulin-What Is Their Role in Spondyloarthropathy?

Magdalena Chmielińska1,2, Marzena Olesińska2, Katarzyna Romanowska-Próchnicka1,2, Dariusz Szukiewicz1.   

Abstract

Haptoglobin (Hp) is an acute phase protein which supports the immune response and protects tissues from free radicals. Its concentration correlates with disease activity in spondyloarthropathies (SpAs). The Hp polymorphism determines the functional differences between Hp1 and Hp2 protein products. The role of the Hp polymorphism has been demonstrated in many diseases. In particular, the Hp 2-2 phenotype has been associated with the unfavorable course of some inflammatory and autoimmune disorders. Its potential role in modulating the immune system in SpA is still unknown. This article contains pathophysiological considerations on the potential relationship between Hp, its polymorphism and SpA.

Entities:  

Keywords:  haptoglobin polymorphism; inflammation; pathogenesis; spondyloarthropathy; zonulin

Year:  2021        PMID： 33800376      PMCID： PMC7962838          DOI： 10.3390/jcm10051131

Source DB:  PubMed          Journal:  J Clin Med        ISSN： 2077-0383            Impact factor:   4.241


  76 in total

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Journal:  Immunol Lett       Date:  2019-01-06       Impact factor: 3.685

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Journal:  Immunology       Date:  2005-02       Impact factor: 7.397

7.  Ankylosing spondylitis macrophage production of higher levels of interleukin-23 in response to lipopolysaccharide without induction of a significant unfolded protein response.

Authors:  Ling Zeng; Mary J Lindstrom; Judith A Smith
Journal:  Arthritis Rheum       Date:  2011-12

8.  Interleukin-23 production in dendritic cells is negatively regulated by protein phosphatase 2A.

Authors:  JiHoon Chang; Timothy J Voorhees; Yusen Liu; Yongge Zhao; Cheong-Hee Chang
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-19       Impact factor: 11.205

Review 9.  Haptoglobin: basic and clinical aspects.

Authors:  Andrew P Levy; Rabea Asleh; Shany Blum; Nina S Levy; Rachel Miller-Lotan; Shiri Kalet-Litman; Yefim Anbinder; Orit Lache; Farid M Nakhoul; Roy Asaf; Dan Farbstein; Mordechai Pollak; Yitzhak Z Soloveichik; Merav Strauss; Jonia Alshiek; Alina Livshits; Avery Schwartz; Hoda Awad; Kheir Jad; Hagit Goldenstein
Journal:  Antioxid Redox Signal       Date:  2010-02       Impact factor: 8.401

10.  Degree of bone marrow oedema in sacroiliac joints of patients with axial spondyloarthritis is linked to gut inflammation and male sex: results from the GIANT cohort.

Authors:  Liesbet Van Praet; Lennart Jans; Philippe Carron; Peggy Jacques; Elien Glorieus; Roos Colman; Heleen Cypers; Herman Mielants; Martine De Vos; Claude Cuvelier; Filip Van den Bosch; Dirk Elewaut
Journal:  Ann Rheum Dis       Date:  2013-11-25       Impact factor: 19.103
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