Literature DB >> 33800359

A Narrative Review on Plasminogen Activator Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target?

Machteld Sillen1, Paul J Declerck1.   

Abstract

Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of plasminogen activators (PAs) and is therefore an important inhibitor of the plasminogen/plasmin system. Being the fast-acting inhibitor of tissue-type PA (tPA), PAI-1 primarily attenuates fibrinolysis. Through inhibition of urokinase-type PA (uPA) and interaction with biological ligands such as vitronectin and cell-surface receptors, the function of PAI-1 extends to pericellular proteolysis, tissue remodeling and other processes including cell migration. This review aims at providing a general overview of the properties of PAI-1 and the role it plays in many biological processes and touches upon the possible use of PAI-1 inhibitors as therapeutics.

Entities:  

Keywords:  PAI-1; aging; cancer; cardiovascular disease; fibrinolysis; fibrosis; inflammation; plasminogen activator inhibitor-1

Mesh：

Substances：

Year:  2021        PMID： 33800359      PMCID： PMC7962805          DOI： 10.3390/ijms22052721

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  152 in total

1.  A regulatory hydrophobic area in the flexible joint region of plasminogen activator inhibitor-1, defined with fluorescent activity-neutralizing ligands. Ligand-induced serpin polymerization.

Authors:  R Egelund; A P Einholm; K E Pedersen; R W Nielsen; A Christensen; J Deinum; P A Andreasen
Journal:  J Biol Chem       Date:  2001-01-25       Impact factor: 5.157

2.  Vitronectin inhibits neutrophil apoptosis through activation of integrin-associated signaling pathways.

Authors:  Hong-Beom Bae; Jaroslaw W Zmijewski; Jessy S Deshane; Degui Zhi; Lawrence C Thompson; Cynthia B Peterson; David D Chaplin; Edward Abraham
Journal:  Am J Respir Cell Mol Biol       Date:  2012-01-26       Impact factor: 6.914

3.  Distribution of plasminogen activator inhibitor (PAI-1) in tissues.

Authors:  A J Simpson; N A Booth; N R Moore; B Bennett
Journal:  J Clin Pathol       Date:  1991-02       Impact factor: 3.411

4.  The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent.

Authors:  Laetitia Devy; Silvia Blacher; Christine Grignet-Debrus; Khalid Bajou; Veronique Masson; Robert D Gerard; Ann Gils; Geert Carmeliet; Peter Carmeliet; Paul J Declerck; Agnès Nöel; Jean-Michel Foidart
Journal:  FASEB J       Date:  2002-02       Impact factor: 5.191

5.  Biochemical importance of glycosylation of plasminogen activator inhibitor-1.

Authors:  Ann Gils; Katrine E Pedersen; Peter Skottrup; Anni Christensen; Dominik Naessens; Johanna Deinum; Jan J Enghild; Paul J Declerck; Peter A Andreasen
Journal:  Thromb Haemost       Date:  2003-08       Impact factor: 5.249

6.  A low-glycemic-index diet reduces plasma plasminogen activator inhibitor-1 activity, but not tissue inhibitor of proteinases-1 or plasminogen activator inhibitor-1 protein, in overweight women.

Authors:  Lotte Jensen; Birgitte Sloth; Inger Krog-Mikkelsen; Anne Flint; Anne Raben; Tine Tholstrup; Nils Brünner; Arne Astrup
Journal:  Am J Clin Nutr       Date:  2008-01       Impact factor: 7.045

7.  Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling.

Authors:  Benjamin S Pedroja; Leah E Kang; Alex O Imas; Peter Carmeliet; Audrey M Bernstein
Journal:  J Biol Chem       Date:  2009-06-01       Impact factor: 5.157

8.  Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1.

Authors:  Li-Jun Ma; Su-Li Mao; Kevin L Taylor; Talerngsak Kanjanabuch; YouFei Guan; YaHua Zhang; Nancy J Brown; Larry L Swift; Owen P McGuinness; David H Wasserman; Douglas E Vaughan; Agnes B Fogo
Journal:  Diabetes       Date:  2004-02       Impact factor: 9.461

9.  The High Affinity Binding Site on Plasminogen Activator Inhibitor-1 (PAI-1) for the Low Density Lipoprotein Receptor-related Protein (LRP1) Is Composed of Four Basic Residues.

Authors:  Peter G W Gettins; Klavs Dolmer
Journal:  J Biol Chem       Date:  2015-11-10       Impact factor: 5.157

10.  Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses.

Authors:  Servet Özcan; Nicola Alessio; Mustafa B Acar; Eda Mert; Fatih Omerli; Gianfranco Peluso; Umberto Galderisi
Journal:  Aging (Albany NY)       Date:  2016-07       Impact factor: 5.682
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  10 in total

1.  Plasma Protein Levels Analysis in Multiple Sclerosis Sardinian Families Identified C9 and CYP24A1 as Candidate Biomarkers.

Authors:  Andrea Nova; Teresa Fazia; Ashley Beecham; Valeria Saddi; Marialuisa Piras; Jacob L McCauley; Carlo Berzuini; Luisa Bernardinelli
Journal:  Life (Basel)       Date:  2022-01-20

2.  Vitronectin and Its Interaction with PAI-1 Suggests a Functional Link to Vascular Changes in AMD Pathobiology.

Authors:  Fabiola Biasella; Tobias Strunz; Christina Kiel; Bernhard H F Weber; Ulrike Friedrich
Journal:  Cells       Date:  2022-05-27       Impact factor: 7.666

Review 3.  PAI-1: A Major Player in the Vascular Dysfunction in Obstructive Sleep Apnea?

Authors:  Mohammad Badran; David Gozal
Journal:  Int J Mol Sci       Date:  2022-05-15       Impact factor: 6.208

Review 4.  The Plasminogen-Activator Plasmin System in Physiological and Pathophysiological Angiogenesis.

Authors:  Asmaa Anwar Ismail; Baraah Tariq Shaker; Khalid Bajou
Journal:  Int J Mol Sci       Date:  2021-12-29       Impact factor: 5.923

5.  SERPINE1 Overexpression Promotes Malignant Progression and Poor Prognosis of Gastric Cancer.

Authors:  Shujia Chen; Yuqiao Li; Yinghui Zhu; Jiayue Fei; Liaoyuan Song; Guoyan Sun; Lianyi Guo; Xiaofei Li
Journal:  J Oncol       Date:  2022-01-29       Impact factor: 4.375

Review 6.  The Molecular Mechanisms of Intestinal Inflammation and Fibrosis in Crohn's Disease.

Authors:  Yuki Hayashi; Hiroshi Nakase
Journal:  Front Physiol       Date:  2022-02-11       Impact factor: 4.566

7.  The Effects and Underlying Mechanisms of Hepatitis B Virus X Gene Mutants on the Development of Hepatocellular Carcinoma.

Authors:  Rui Pu; Wenbin Liu; Xinyu Zhou; Xi Chen; Xiaomei Hou; Shiliang Cai; Liping Chen; Jianfeng Wu; Fan Yang; Xiaojie Tan; Jianhua Yin; Xin Wang; Guangwen Cao
Journal:  Front Oncol       Date:  2022-02-10       Impact factor: 6.244

8.  Interplay of Helicobacter pylori, fibroblasts, and cancer cells induces fibroblast activation and serpin E1 expression by cancer cells to promote gastric tumorigenesis.

Authors:  Xueshu Chen; Wei Chen; Yan Zhao; Qinrong Wang; Wenling Wang; Yining Xiang; Hang Yuan; Yuan Xie; Jianjiang Zhou
Journal:  J Transl Med       Date:  2022-07-21       Impact factor: 8.440

9.  Heritability Estimation of Multiple Sclerosis Related Plasma Protein Levels in Sardinian Families with Immunochip Genotyping Data.

Authors:  Andrea Nova; Giulia Nicole Baldrighi; Teresa Fazia; Francesca Graziano; Valeria Saddi; Marialuisa Piras; Ashley Beecham; Jacob L McCauley; Luisa Bernardinelli
Journal:  Life (Basel)       Date:  2022-07-21

10.  Adipokines, and not vitamin D, associate with antibody immune responses following dual BNT162b2 vaccination within individuals younger than 60 years.

Authors:  Mariana Pavel-Tanasa; Daniela Constantinescu; Corina Maria Cianga; Ecaterina Anisie; Ana Irina Mereuta; Cristina Gabriela Tuchilus; Petru Cianga
Journal:  Front Immunol       Date:  2022-09-02       Impact factor: 8.786
  10 in total

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