| Literature DB >> 33799967 |
Chiara Mele1, Valeria Pingue2, Marina Caputo3,4, Marco Zavattaro4,5, Loredana Pagano5, Flavia Prodam3,4, Antonio Nardone1,2, Gianluca Aimaretti4,6, Paolo Marzullo4,6,7.
Abstract
The incidence of traumatic brain injury (TBI) has increased over the last years with an important impact on public health. Many preclinical and clinical studies identified multiple and heterogeneous TBI-related pathophysiological mechanisms that are responsible for functional, cognitive, and behavioral alterations. Recent evidence has suggested that post-TBI neuroinflammation is responsible for several long-term clinical consequences, including hypopituitarism. This review aims to summarize current evidence on TBI-induced neuroinflammation and its potential role in determining hypothalamic-pituitary dysfunctions.Entities:
Keywords: hypopituitarism; neuroinflammation; traumatic brain injury
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Year: 2021 PMID: 33799967 PMCID: PMC7961958 DOI: 10.3390/ijms22052686
Source DB: PubMed Journal: Int J Mol Sci ISSN: 1422-0067 Impact factor: 5.923