Dorota Kowalczuk1, Agata Gładysz1, Monika Pitucha2, Daniel M Kamiński3, Agnieszka Barańska4, Bartłomiej Drop4. 1. Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University, Jaczewskiego 4, 20-090 Lublin, Poland. 2. Independent Radiopharmacy Unit, Faculty of Pharmacy, Medical University, Chodzki 4A, 20-093 Lublin, Poland. 3. Department of Chemistry, University of Life Sciences in Lublin, Akademicka 15, 20-950 Lublin, Poland. 4. Department of Informatics and Medical Statistics, Medical University, Jaczewskiego 4, 20-090 Lublin, Poland.
Abstract
Bacterial strains become resistant to almost all classes of antibiotics, which makes it necessary to look for new substitutes. The non-absorbable ciprofloxacin-biguanide bismuth complex, used locally, may be a good alternative to a conventional therapy. The purpose of this study was to study the structure of the proposed ciprofloxacin (CIP) -bismuth(III)-chlorhexidine (CHX) composite (CIP-Bi-CHX). The spectroscopic techniques such as UV-VIS (ultraviolet-visible) spectroscopy, FTIR (Fourier-transform infrared) spectroscopy and NMR (Nuclear Magnetic Resonance) spectroscopy were used for structure characterization of the hybrid compound. The performed analysis confirmed the presence of the two active components-CIP and CHX and revealed the possible coordination sites of the ligands with bismuth ion in the metallo-organic structure. Spectroscopic study showed that the complexation between Bi(III) and CIP occurs through the carboxylate and ketone groups of the quinolone ring, while CHX combines with the central ion via the biguanide moieties.
Bacterial strains become resistant to almost allclclass="Chemical">asses on class="Chemical">f antibiotics, which makes it necessary to look for new substitutes. The non-absorbable ciprofloxacin-biguanide bismuth complex, used locally, may be a good alternative to a conventional therapy. The purpose of this study was to study the structure of the proposed ciprofloxacin (CIP) -bismuth(III)-chlorhexidine (CHX) composite (CIP-Bi-CHX). The spectroscopic techniques such as UV-VIS (ultraviolet-visible) spectroscopy, FTIR (Fourier-transform infrared) spectroscopy and NMR (Nuclear Magnetic Resonance) spectroscopy were used for structure characterization of the hybrid compound. The performed analysis confirmed the presence of the two active components-CIP and CHX and revealed the possible coordination sites of the ligands with bismuth ion in the metallo-organic structure. Spectroscopic study showed that the complexation between Bi(III) and CIP occurs through the carboxylate and ketone groups of the quinolone ring, while CHX combines with the central ion via the biguanide moieties.
Authors: Sharad P Parwe; Priti N Chaudhari; Kavita K Mohite; Balaji S Selukar; Smita S Nande; Baijayantimala Garnaik Journal: Int J Nanomedicine Date: 2014-03-26