Literature DB >> 33799936

1,2,4-Triazoles as Important Antibacterial Agents.

Małgorzata Strzelecka1, Piotr Świątek1.   

Abstract

The global spread of drug resistance in bacteria requires new potent and safe antimicrobial agents. Compounds containing the 1,2,4-triazole ring in their structure are characterised by multidirectional biological activity. A large volume of research on triazole and their derivatives has been carried out, proving significant antibacterial activity of this heterocyclic core. This review is useful for further investigations on this scaffold to harness its optimum antibacterial potential. Moreover, rational design and development of the novel antibacterial agents incorporating 1,2,4-triazole can help in dealing with the escalating problems of microbial resistance.

Entities:  

Keywords:  1,2,4-triazole; antibacterial drugs; antimicrobial activity

Year:  2021        PMID： 33799936      PMCID： PMC7999634          DOI： 10.3390/ph14030224

Source DB:  PubMed          Journal:  Pharmaceuticals (Basel)        ISSN： 1424-8247


  50 in total

1.  Synthesis of some new [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles starting from 5-nitro-2-furoic acid and evaluation of their antimicrobial activity.

Authors:  Sahar M I Badr; Rasha M Barwa
Journal:  Bioorg Med Chem       Date:  2011-06-16       Impact factor: 3.641

2.  Studies on the synthesis and antibacterial activity of 3,6-disubstituted 1,2,4-triazolo[3,4-b]1,3,4-thiadiazoles.

Authors:  Tomasz Plech; Monika Wujec; Urszula Kosikowska; Anna Malm; Barbara Kaproń
Journal:  Eur J Med Chem       Date:  2011-11-06       Impact factor: 6.514

3.  Analgesic activity of some 1,2,4-triazole heterocycles clubbed with pyrazole, tetrazole, isoxazole and pyrimidine.

Authors:  Shantaram Gajanan Khanage; Appala Raju; Popat Baban Mohite; Ramdas Bhanudas Pandhare
Journal:  Adv Pharm Bull       Date:  2013-02-07

4.  Search for factors affecting antibacterial activity and toxicity of 1,2,4-triazole-ciprofloxacin hybrids.

Authors:  Tomasz Plech; Barbara Kaproń; Agata Paneth; Urszula Kosikowska; Anna Malm; Aleksandra Strzelczyk; Paweł Stączek; Łukasz Świątek; Barbara Rajtar; Małgorzata Polz-Dacewicz
Journal:  Eur J Med Chem       Date:  2015-04-29       Impact factor: 6.514

5.  Synthesis and biological evaluation of dihydroindeno and indeno [1,2-e] [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazines as antimicrobial agents.

Authors:  Om Prakash; Deepak K Aneja; Khalid Hussain; Poonam Lohan; Pooja Ranjan; Sanjiv Arora; Chetan Sharma; Kamal R Aneja
Journal:  Eur J Med Chem       Date:  2011-08-22       Impact factor: 6.514

6.  Design, synthesis and 3D-QSAR studies of new diphenylamine containing 1,2,4-triazoles as potential antitubercular agents.

Authors:  K Mohan Krishna; Bharathkumar Inturi; Gurubasavaraj V Pujar; Madhusudan N Purohit; G S Vijaykumar
Journal:  Eur J Med Chem       Date:  2014-07-16       Impact factor: 6.514

7.  Design, Synthesis and Evaluation of Triazole-Pyrimidine Analogues as SecA Inhibitors.

Authors:  Jianmei Cui; Jinshan Jin; Arpana Sagwal Chaudhary; Ying-hsin Hsieh; Hao Zhang; Chaofeng Dai; Krishna Damera; Weixuan Chen; Phang C Tai; Binghe Wang
Journal:  ChemMedChem       Date:  2015-11-26       Impact factor: 3.466

8.  Synthesis, antimicrobial activity and molecular modeling study of 3-(5-amino-(2H)-1,2,4-triazol-3-yl]-naphthyridinones as potential DNA-gyrase inhibitors.

Authors:  Noha G Mohamed; Mahmoud M Sheha; Hoda Y Hassan; Lina Jamil M Abdel-Hafez; Farghaly A Omar
Journal:  Bioorg Chem       Date:  2018-09-06       Impact factor: 5.275

9.  New methyl 5-(halomethyl)-1-aryl-1H-1,2,4-triazole-3-carboxylates as selective COX-2 inhibitors and anti-inflammatory agents: Design, synthesis, biological evaluation, and docking study.

Authors:  Sin-Min Li; Shuo-En Tsai; Chia-Yin Chiang; Cheng-Yen Chung; Tsung-Jui Chuang; Ching-Chun Tseng; Wen-Ping Jiang; Guan-Jhong Huang; Chin-Yu Lin; Ya-Chen Yang; Mao-Tsu Fuh; Fung-Fuh Wong
Journal:  Bioorg Chem       Date:  2020-10-02       Impact factor: 5.275

10.  New Benzimidazole-1,2,4-Triazole Hybrid Compounds: Synthesis, Anticandidal Activity and Cytotoxicity Evaluation.

Authors:  Hülya Karaca Gençer; Ulviye Acar Çevik; Serkan Levent; Begüm Nurpelin Sağlık; Büşra Korkut; Yusuf Özkay; Sinem Ilgın; Yusuf Öztürk
Journal:  Molecules       Date:  2017-03-27       Impact factor: 4.411
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  7 in total

1.  Synthesis and Antimicrobial Activity of 1,3,4-Oxadiazoline, 1,3-Thiazolidine, and 1,2,4-Triazoline Double-Tailed Acyclo C-Nucleosides.

Authors:  Adel Z Nasr; Abeer Farahat; Mohamed A Zein; El-Sayed M Abdelrehim
Journal:  ACS Omega       Date:  2022-05-14

2.  Antimicrobial efficacy of Egyptian Eremina desertorum and Helix aspersa snail mucus with a novel approach to their anti-inflammatory and wound healing potencies.

Authors:  Nessma A El-Zawawy; Mahy M Mona
Journal:  Sci Rep       Date:  2021-12-21       Impact factor: 4.379

Review 3.  Novel 1, 2, 4-Triazoles as Antifungal Agents.

Authors:  Zahra Kazeminejad; Mahrokh Marzi; Abolfazl Shiroudi; Seyed Amin Kouhpayeh; Mojtaba Farjam; Elham Zarenezhad
Journal:  Biomed Res Int       Date:  2022-03-22       Impact factor: 3.411

4.  Chemical Composition and Biological Evaluation of Typha domingensis Pers. to Ameliorate Health Pathologies: In Vitro and In Silico Approaches.

Authors:  Rizwana Dilshad; Kashif-Ur-Rehman Khan; Laiba Saeed; Asmaa E Sherif; Saeed Ahmad; Chitchamai Ovatlarnporn; Jawad Nasim; Musaddique Hussain; Bilal Ahmad Ghalloo; Abdul Basit; Imran Mukhtar
Journal:  Biomed Res Int       Date:  2022-07-14       Impact factor: 3.246

Review 5.  Synthesis methods of 1,2,3-/1,2,4-triazoles: A review.

Authors:  Jinlian Dai; Sen Tian; Xueqing Yang; Zongliang Liu
Journal:  Front Chem       Date:  2022-09-26       Impact factor: 5.545

6.  Structural and Energetic Properties of Weak Noncovalent Interactions in Two Closely Related 3,6-Disubstituted-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole Derivatives: In Vitro Cyclooxygenase Activity, Crystallography, and Computational Investigations.

Authors:  Lamya H Al-Wahaibi; Sekar Karthikeyan; Olivier Blacque; Amal A El-Masry; Hanan M Hassan; M Judith Percino; Ali A El-Emam; Subbiah Thamotharan
Journal:  ACS Omega       Date:  2022-09-16

7.  Regioselective Synthesis of 5-Trifluoromethyl 1,2,4-Triazoles via [3 + 2]-Cycloaddition of Nitrile Imines with CF3CN.

Authors:  Bo Lin; Zipeng Zhang; Yunfei Yao; Yi You; Zhiqiang Weng
Journal:  Molecules       Date:  2022-10-04       Impact factor: 4.927
  7 in total

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