Literature DB >> 33799894

Mitochondrial Unfolded Protein Responses in White Adipose Tissue: Lipoatrophy, Whole-Body Metabolism and Lifespan.

Masaki Kobayashi1, Yuichiro Nezu1, Ryoma Tagawa1, Yoshikazu Higami1,2.   

Abstract

The mitochondrial unfolded protein response (UPRmt) is a stress response mediated by the expression of genes such as chaperones, proteases, and mitokines to maintain mitochondrial proteostasis. Certain genetically modified mice, which defect mitochondrial proteins specifically in adipocytes, developed atrophy of the white adipose tissue, resisted diet-induced obesity, and had altered whole-body metabolism. UPRmt, which has beneficial functions for living organisms, is termed "mitohormesis", but its specific characteristics and detailed regulatory mechanism have not been elucidated to date. In this review, we discuss the function of UPRmt in adipose atrophy (lipoatrophy), whole-body metabolism, and lifespan based on the concept of mitohormesis.

Entities:  

Keywords:  lipoatrophy; mitochondrial unfolded protein response (UPRmt); mitohormesis; mitokine; white adipose tissue (WAT)

Mesh：

Substances：

Year:  2021        PMID： 33799894      PMCID： PMC7998111          DOI： 10.3390/ijms22062854

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  68 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

3.  An adipocyte-specific defect in oxidative phosphorylation increases systemic energy expenditure and protects against diet-induced obesity in mouse models.

Authors:  Min Jeong Choi; Saet-Byel Jung; Seong Eun Lee; Seul Gi Kang; Ju Hee Lee; Min Jeong Ryu; Hyo Kyun Chung; Joon Young Chang; Yong Kyung Kim; Hyun Jung Hong; Hail Kim; Hyun Jin Kim; Chul-Ho Lee; Adil Mardinoglu; Hyon-Seung Yi; Minho Shong
Journal:  Diabetologia       Date:  2020-01-10       Impact factor: 10.122

4.  Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.

Authors:  Kohjiro Ueki; Terumasa Okada; Jiang Hu; Chong Wee Liew; Anke Assmann; Gabriella M Dahlgren; Jennifer L Peters; Jonathan G Shackman; Min Zhang; Isabella Artner; Leslie S Satin; Roland Stein; Martin Holzenberger; Robert T Kennedy; C Ronald Kahn; Rohit N Kulkarni
Journal:  Nat Genet       Date:  2006-04-23       Impact factor: 38.330

5.  GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance.

Authors:  Harding H Luan; Andrew Wang; Brandon K Hilliard; Fernando Carvalho; Connor E Rosen; Amy M Ahasic; Erica L Herzog; Insoo Kang; Margaret A Pisani; Shuang Yu; Cuiling Zhang; Aaron M Ring; Lawrence H Young; Ruslan Medzhitov
Journal:  Cell       Date:  2019-08-08       Impact factor: 41.582

6.  FGF-21 as a novel metabolic regulator.

Authors:  Alexei Kharitonenkov; Tatiyana L Shiyanova; Anja Koester; Amy M Ford; Radmila Micanovic; Elizabeth J Galbreath; George E Sandusky; Lisa J Hammond; Julie S Moyers; Rebecca A Owens; Jesper Gromada; Joseph T Brozinick; Eric D Hawkins; Victor J Wroblewski; De-Shan Li; Farrokh Mehrbod; S Richard Jaskunas; Armen B Shanafelt
Journal:  J Clin Invest       Date:  2005-05-02       Impact factor: 14.808

7.  Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice.

Authors:  Xingxing Liu; Ning Jiang; Bryan Hughes; Eve Bigras; Eric Shoubridge; Siegfried Hekimi
Journal:  Genes Dev       Date:  2005-09-29       Impact factor: 11.361

8.  Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.

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Journal:  Mol Cell       Date:  2000-07       Impact factor: 17.970

9.  Ppargamma2 is a key driver of longevity in the mouse.

Authors:  Carmen Argmann; Radu Dobrin; Sami Heikkinen; Aurélie Auburtin; Laurent Pouilly; Terrie-Anne Cock; Hana Koutnikova; Jun Zhu; Eric E Schadt; Johan Auwerx
Journal:  PLoS Genet       Date:  2009-12-04       Impact factor: 5.917

10.  Adipose tissue mitochondrial dysfunction triggers a lipodystrophic syndrome with insulin resistance, hepatosteatosis, and cardiovascular complications.

Authors:  Cecile Vernochet; Federico Damilano; Arnaud Mourier; Olivier Bezy; Marcelo A Mori; Graham Smyth; Anthony Rosenzweig; Nils-Göran Larsson; C Ronald Kahn
Journal:  FASEB J       Date:  2014-07-08       Impact factor: 5.191
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  4 in total

Review 1.  Contribution of PGC-1α to Obesity- and Caloric Restriction-Related Physiological Changes in White Adipose Tissue.

Authors:  Masaki Kobayashi; Yusuke Deguchi; Yuka Nozaki; Yoshikazu Higami
Journal:  Int J Mol Sci       Date:  2021-06-02       Impact factor: 5.923

Review 2.  The Pancreatic ß-cell Response to Secretory Demands and Adaption to Stress.

Authors:  Michael A Kalwat; Donalyn Scheuner; Karina Rodrigues-Dos-Santos; Decio L Eizirik; Melanie H Cobb
Journal:  Endocrinology       Date:  2021-11-01       Impact factor: 4.736

3.  SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin.

Authors:  Hao Chen; Dong-Ming Zhang; Zhi-Ping Zhang; Ming-Zhang Li; Hai-Feng Wu
Journal:  Genes Genomics       Date:  2021-08-02       Impact factor: 1.839

Review 4.  Molecular and Cellular Bases of Lipodystrophy Syndromes.

Authors:  Jamila Zammouri; Camille Vatier; Emilie Capel; Martine Auclair; Caroline Storey-London; Elise Bismuth; Héléna Mosbah; Bruno Donadille; Sonja Janmaat; Bruno Fève; Isabelle Jéru; Corinne Vigouroux
Journal:  Front Endocrinol (Lausanne)       Date:  2022-01-03       Impact factor: 5.555
  4 in total

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