Literature DB >> 33799842

Pulsed Broad-Spectrum UV Light Effectively Inactivates SARS-CoV-2 on Multiple Surfaces and N95 Material.

Alexander S Jureka1, Caroline G Williams1, Christopher F Basler1.   

Abstract

The ongoing SARS-CoV-2 pandemic has resulted in an increased need for technologies capable of efficiently disinfecting public spaces as well as personal protective equipment. UV light disinfection is a well-established method for inactivating respiratory viruses. Here, we have determined that broad-spectrum, pulsed UV light is effective at inactivating SARS-CoV-2 on multiple surfaces in vitro. For hard, non-porous surfaces, we observed that SARS-CoV-2 was inactivated to undetectable levels on plastic and glass with a UV dose of 34.9 mJ/cm2 and stainless steel with a dose of 52.5 mJ/cm2. We also observed that broad-spectrum, pulsed UV light is effective at reducing SARS-CoV-2 on N95 respirator material to undetectable levels with a dose of 103 mJ/cm2. We included UV dosimeter cards that provide a colorimetric readout of UV dose and demonstrated their utility as a means to confirm desired levels of exposure were reached. Together, the results presented here demonstrate that broad-spectrum, pulsed UV light is an effective technology for the in vitro inactivation of SARS-CoV-2 on multiple surfaces.

Entities:  

Keywords:  COVID-19; SARS-CoV-2; coronavirus; inactivation; ultraviolet

Mesh:

Year:  2021        PMID: 33799842      PMCID: PMC7998866          DOI: 10.3390/v13030460

Source DB:  PubMed          Journal:  Viruses        ISSN: 1999-4915            Impact factor:   5.048


  36 in total

1.  Principles of selective inactivation of viral genome. I. UV-induced inactivation of influenza virus.

Authors:  E I Budowsky; S E Bresler; E A Friedman; N V Zheleznova
Journal:  Arch Virol       Date:  1981       Impact factor: 2.574

2.  Air, Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From a Symptomatic Patient.

Authors:  Sean Wei Xiang Ong; Yian Kim Tan; Po Ying Chia; Tau Hong Lee; Oon Tek Ng; Michelle Su Yen Wong; Kalisvar Marimuthu
Journal:  JAMA       Date:  2020-04-28       Impact factor: 56.272

3.  Aerosol and surface contamination of SARS-CoV-2 observed in quarantine and isolation care.

Authors:  Joshua L Santarpia; Danielle N Rivera; Vicki L Herrera; M Jane Morwitzer; Hannah M Creager; George W Santarpia; Kevin K Crown; David M Brett-Major; Elizabeth R Schnaubelt; M Jana Broadhurst; James V Lawler; St Patrick Reid; John J Lowe
Journal:  Sci Rep       Date:  2020-07-29       Impact factor: 4.379

4.  Effectiveness of Ultraviolet-C Light and a High-Level Disinfection Cabinet for Decontamination of N95 Respirators.

Authors:  Jennifer L Cadnum; Daniel F Li; Sarah N Redmond; Amrita R John; Basya Pearlmutter; Curtis J Donskey
Journal:  Pathog Immun       Date:  2020-04-20

5.  UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication.

Authors:  Mara Biasin; Andrea Bianco; Giovanni Pareschi; Adalberto Cavalleri; Claudia Cavatorta; Claudio Fenizia; Paola Galli; Luigi Lessio; Manuela Lualdi; Enrico Tombetti; Alessandro Ambrosi; Edoardo Maria Alberto Redaelli; Irma Saulle; Daria Trabattoni; Alessio Zanutta; Mario Clerici
Journal:  Sci Rep       Date:  2021-03-18       Impact factor: 4.379

6.  Inactivation of Severe Acute Respiratory Syndrome Coronavirus 2 by WHO-Recommended Hand Rub Formulations and Alcohols.

Authors:  Annika Kratzel; Daniel Todt; Philip V'kovski; Silvio Steiner; Mitra Gultom; Tran Thi Nhu Thao; Nadine Ebert; Melle Holwerda; Jörg Steinmann; Daniela Niemeyer; Ronald Dijkman; Günter Kampf; Christian Drosten; Eike Steinmann; Volker Thiel; Stephanie Pfaender
Journal:  Emerg Infect Dis       Date:  2020-06-21       Impact factor: 6.883

7.  Ultraviolet germicidal irradiation: Possible method for respirator disinfection to facilitate reuse during the COVID-19 pandemic.

Authors:  Iltefat H Hamzavi; Alexis B Lyons; Indermeet Kohli; Shanthi Narla; Angela Parks-Miller; Joel M Gelfand; Henry W Lim; David M Ozog
Journal:  J Am Acad Dermatol       Date:  2020-04-01       Impact factor: 11.527

8.  Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1.

Authors:  Neeltje van Doremalen; Trenton Bushmaker; Dylan H Morris; Myndi G Holbrook; Amandine Gamble; Brandi N Williamson; Azaibi Tamin; Jennifer L Harcourt; Natalie J Thornburg; Susan I Gerber; James O Lloyd-Smith; Emmie de Wit; Vincent J Munster
Journal:  N Engl J Med       Date:  2020-03-17       Impact factor: 91.245

9.  Effectiveness of 222-nm ultraviolet light on disinfecting SARS-CoV-2 surface contamination.

Authors:  Hiroki Kitagawa; Toshihito Nomura; Tanuza Nazmul; Keitaro Omori; Norifumi Shigemoto; Takemasa Sakaguchi; Hiroki Ohge
Journal:  Am J Infect Control       Date:  2020-09-04       Impact factor: 2.918

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  4 in total

1.  SARS-CoV-2 inactivation by ultraviolet radiation and visible light is dependent on wavelength and sample matrix.

Authors:  Michael A Schuit; Thomas C Larason; Melissa L Krause; Brian M Green; Brian P Holland; Stewart P Wood; Steven Grantham; Yuqin Zong; Clarence J Zarobila; Denise L Freeburger; David M Miller; Jordan K Bohannon; Shanna A Ratnesar-Shumate; Ernest R Blatchley; Xing Li; Paul A Dabisch; C Cameron Miller
Journal:  J Photochem Photobiol B       Date:  2022-06-23       Impact factor: 6.814

Review 2.  Disinfection and decontamination in the context of SARS-CoV-2-specific data.

Authors:  Nevio Cimolai
Journal:  J Med Virol       Date:  2022-07-18       Impact factor: 20.693

3.  Specificity of UV-C LED disinfection efficacy for three N95 respirators.

Authors:  C Carolina Ontiveros; David C Shoults; Sean MacIsaac; Kyle D Rauch; Crystal L Sweeney; Amina K Stoddart; Graham A Gagnon
Journal:  Sci Rep       Date:  2021-07-28       Impact factor: 4.379

4.  Ultraviolet-C Irradiation, Heat, and Storage as Potential Methods of Inactivating SARS-CoV-2 and Bacterial Pathogens on Filtering Facepiece Respirators.

Authors:  Rhodri Harfoot; Deborah B Y Yung; William A Anderson; Cervantée E K Wild; Nicolene Coetzee; Leonor C Hernández; Blair Lawley; Daniel Pletzer; José G B Derraik; Yvonne C Anderson; Miguel E Quiñones-Mateu
Journal:  Pathogens       Date:  2022-01-10
  4 in total

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