Literature DB >> 33798426

Tête-à-tête with CtBP dimers.

Ana-Maria Raicu1, Kalynn M Bird2, David N Arnosti3.   

Abstract

Jecrois et al. (2020) use cryoelectron microscopy to illuminate the tetrameric conformation of the CtBP2 transcriptional corepressor, a protein frequently overexpressed in human cancers. The in vivo functional characterization of tetramer-destabilizing mutants indicates that tetramerization is a physiologically important process, critical for CtBP control of gene regulation and cell migration.
Copyright © 2021 Elsevier Ltd. All rights reserved.

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Year:  2021        PMID： 33798426      PMCID： PMC9069854          DOI： 10.1016/j.str.2021.03.006

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  10 in total

1.  Conserved catalytic and C-terminal regulatory domains of the C-terminal binding protein corepressor fine-tune the transcriptional response in development.

Authors:  Yang W Zhang; David N Arnosti
Journal:  Mol Cell Biol       Date:  2010-11-15       Impact factor: 4.272

2.  Assembly of human C-terminal binding protein (CtBP) into tetramers.

Authors:  Andrew G Bellesis; Anne M Jecrois; Janelle A Hayes; Celia A Schiffer; William E Royer
Journal:  J Biol Chem       Date:  2018-04-26       Impact factor: 5.157

3.  Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase.

Authors:  Vivek Kumar; Justin E Carlson; Kenneth A Ohgi; Thomas A Edwards; David W Rose; Carlos R Escalante; Michael G Rosenfeld; Aneel K Aggarwal
Journal:  Mol Cell       Date:  2002-10       Impact factor: 17.970

4.  Regulation of corepressor function by nuclear NADH.

Authors:  Qinghong Zhang; David W Piston; Richard H Goodman
Journal:  Science       Date:  2002-02-14       Impact factor: 47.728

5.  C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs.

Authors:  Madeleine Grooteclaes; Quinn Deveraux; Jeffrey Hildebrand; Qinghong Zhang; Richard H Goodman; Steven M Frisch
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-03       Impact factor: 11.205

6.  Developmental expression and phylogenetic conservation of alternatively spliced forms of the C-terminal binding protein corepressor.

Authors:  Priya Mani-Telang; David N Arnosti
Journal:  Dev Genes Evol       Date:  2006-11-21       Impact factor: 0.900

7.  Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor.

Authors:  Clark C Fjeld; William T Birdsong; Richard H Goodman
Journal:  Proc Natl Acad Sci U S A       Date:  2003-07-18       Impact factor: 11.205

8.  Nicotinamide adenine dinucleotide-induced multimerization of the co-repressor CtBP1 relies on a switching tryptophan.

Authors:  Dana L Madison; Jacqueline A Wirz; Don Siess; James R Lundblad
Journal:  J Biol Chem       Date:  2013-08-12       Impact factor: 5.157

9.  A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis.

Authors:  J M Boyd; T Subramanian; U Schaeper; M La Regina; S Bayley; G Chinnadurai
Journal:  EMBO J       Date:  1993-02       Impact factor: 11.598

10.  Cryo-EM structure of CtBP2 confirms tetrameric architecture.

Authors:  Anne M Jecrois; M Michael Dcona; Xiaoyan Deng; Dipankar Bandyopadhyay; Steven R Grossman; Celia A Schiffer; William E Royer
Journal:  Structure       Date:  2020-12-01       Impact factor: 5.871
  10 in total

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