Calcineurin inhibitors nephrotoxicity revisited.

The journey of calcineurin inhibitors (CNIs) nephrotoxicity as an entity in the field of solid organ transplantation is a complicated story. The clinical use of CNIs has always been embedded with the idea that these molecules, especially at high doses, induce arterioles vasoconstriction, kill myocytes, and promote ischemia, ultimately leading to tubular atrophy, stripped fibrosis and ischemic glomerulosclerosis. This article is protected by copyright. All rights reserved.