Sanusi Andah Salihu1, Homanaz Ghafari1, Mahnaz Ahmadimanesh2,3, Narges K Gortany1, Hamed Shafaroodi4, Mahmoud Ghazi-Khansari5. 1. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran. 2. Department of Pharmacodynamics and Toxicology, Mashhad University of Medical Sciences, Mashhad, Iran. 3. Food and Drug Control Laboratory, Food and Drug Vice Presidency, Mashhad University of Medical Sciences, Mashhad, Iran. 4. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran. hshafaroodi@sina.tums.ac.ir. 5. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran. ghazikha@sina.tums.ac.ir.
Abstract
RATIONALE: Major depressive disorder (MDD) is a debilitating disorder with adverse effects on mood, memory, and quality of life. OBJECTIVES: In this study, the antidepressant potential of glatiramer acetate (GA), a drug used in the management of multiple sclerosis, was investigated in acute and chronic models of depression in male mice. The acute antidepressant screening was performed with the forced swim (FST) and tail suspension (TST) tests. In the chronic phase, post-weaning social isolation (SI) was used to induce depressive-/anxiety-like behaviors. METHODS: Mice were reared in two different groups of social (SG) and isolated (IG) for 4 weeks. IG mice were treated with 0.5, 1.0, and 2.0 mg/kg of GA for the last 2 weeks of the SI period. Animals were assessed by the behavioral tests of depression, anxiety, learning, and memory, and hippocampal brain-derived neurotrophic factor (BDNF) level was measured. RESULTS: The acute tests confirmed the antidepressant potential of GA. In the chronic phase, GA could reduce immobility time in FST (P < 0.05), increase exploration activity in open field test (P < 0.05), increase open arms duration (P < 0.05) and entries in elevated plus maze (P<0.001), and improve memory and learning in passive avoidance test (P < 0.05). The BDNF level was increased in IG mice and decreased in IG mice treated with GA. CONCLUSIONS: Our results showed that GA improved depressive-/anxiety-like behaviors and cognitive dysfunction of SI reared mice without increasing the BDNF level which may be associated with other mechanisms of actions of GA.
RATIONALE: Major depressive disorder (MDD) is a debilitating disorder with adverse effects on mood, memory, and quality of life. OBJECTIVES: In this study, the antidepressant potential of glatiramer acetate (GA), a drug used in the management of multiple sclerosis, was investigated in acute and chronic models of depression in male mice. The acute antidepressant screening was performed with the forced swim (FST) and tail suspension (TST) tests. In the chronic phase, post-weaning social isolation (SI) was used to induce depressive-/anxiety-like behaviors. METHODS:Mice were reared in two different groups of social (SG) and isolated (IG) for 4 weeks. IG mice were treated with 0.5, 1.0, and 2.0 mg/kg of GA for the last 2 weeks of the SI period. Animals were assessed by the behavioral tests of depression, anxiety, learning, and memory, and hippocampal brain-derived neurotrophic factor (BDNF) level was measured. RESULTS: The acute tests confirmed the antidepressant potential of GA. In the chronic phase, GA could reduce immobility time in FST (P < 0.05), increase exploration activity in open field test (P < 0.05), increase open arms duration (P < 0.05) and entries in elevated plus maze (P<0.001), and improve memory and learning in passive avoidance test (P < 0.05). The BDNF level was increased in IG mice and decreased in IG mice treated with GA. CONCLUSIONS: Our results showed that GA improved depressive-/anxiety-like behaviors and cognitive dysfunction of SI reared mice without increasing the BDNF level which may be associated with other mechanisms of actions of GA.
Authors: F Biggio; M G Pisu; A Garau; G Boero; V Locci; M C Mostallino; P Olla; C Utzeri; M Serra Journal: Eur Neuropsychopharmacol Date: 2014-04-05 Impact factor: 4.600
Authors: Christine Bell; James Anderson; Tanmoy Ganguly; James Prescott; Ishan Capila; Jonathan C Lansing; Richard Sachleben; Mani Iyer; Ian Fier; James Roach; Kristina Storey; Paul Miller; Steven Hall; Daniel Kantor; Benjamin M Greenberg; Kavita Nair; Joseph Glajch Journal: J Pharm Pract Date: 2017-08-29