| Literature DB >> 33797393 |
Natalia Fintelman-Rodrigues, Aline P D da Silva, Monique Cristina Dos Santos, Felipe B Saraiva, Marcelo A Ferreira, João Gesto, Danielle A S Rodrigues, André M Vale, Isaclaudia G de Azevedo, Vinícius C Soares, Hui Jiang, Hongdong Tan, Diogo A Tschoeke, Carolina Q Sacramento, Fernando A Bozza, Carlos M Morel, Patrícia T Bozza, Thiago Moreno L Souza.
Abstract
The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented.Entities:
Keywords: Brazil; COVID-19; SARS-CoV-2; coronavirus disease; humoral response; next-generation sequencing; reinfection; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses
Year: 2021 PMID： 33797393 DOI： 10.3201/eid2705.204912
Source DB: PubMed Journal: Emerg Infect Dis ISSN： 1080-6040 Impact factor: 6.883