Literature DB >> 33796875

Capturing pathogenic immune cells before they home to brain.

Lawrence Steinman1.   

Abstract

In this issue, Kaufmann and colleagues1 describe a population of immune cells that home to brain in multiple sclerosis (MS). Using an approved therapeutic, targeting α4β1integrin, they demonstrated how to trap these cells in blood, opening the possibility for their elimination before they cross into brain.

Entities:  

Mesh：

Year:  2021        PMID： 33796875      PMCID： PMC8011039          DOI： 10.1016/j.medj.2021.02.005

Source DB:  PubMed          Journal:  Med (N Y)        ISSN： 2666-6340


  9 in total

1.  A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis.

Authors:  Laura Kolb; Elif Diken; Christina Krienke; Michael Streuber; Sarah Kirchhoff; Thomas Bukur; Özlem Akilli-Öztürk; Lena M Kranz; Hendrik Berger; Jutta Petschenka; Mustafa Diken; Sebastian Kreiter; Nir Yogev; Ari Waisman; Katalin Karikó; Özlem Türeci; Ugur Sahin
Journal:  Science       Date:  2021-01-08       Impact factor: 47.728

Review 2.  Immunology of relapse and remission in multiple sclerosis.

Authors:  Lawrence Steinman
Journal:  Annu Rev Immunol       Date:  2014-01-15       Impact factor: 28.527

3.  Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models.

Authors:  Bahareh Ajami; Nikolay Samusik; Peter Wieghofer; Peggy P Ho; Andrea Crotti; Zach Bjornson; Marco Prinz; Wendy J Fantl; Garry P Nolan; Lawrence Steinman
Journal:  Nat Neurosci       Date:  2018-03-05       Impact factor: 24.884

Review 4.  Antigen-specific tolerance to self-antigens in protein replacement therapy, gene therapy and autoimmunity.

Authors:  Lawrence Steinman; Peggy P Ho; William H Robinson; Paul J Utz; Pablo Villoslada
Journal:  Curr Opin Immunol       Date:  2019-08-30       Impact factor: 7.486

5.  Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis.

Authors:  Hideki Garren; William H Robinson; Eva Krasulová; Eva Havrdová; Congor Nadj; Krzysztof Selmaj; Jacek Losy; Ilinka Nadj; Ernst-Wilhelm Radue; Brian A Kidd; Jill Gianettoni; Karen Tersini; Paul J Utz; Frank Valone; Lawrence Steinman
Journal:  Ann Neurol       Date:  2008-05       Impact factor: 10.422

6.  Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis.

Authors:  Ivan Jelcic; Faiez Al Nimer; Jian Wang; Verena Lentsch; Raquel Planas; Ilijas Jelcic; Aleksandar Madjovski; Sabrina Ruhrmann; Wolfgang Faigle; Katrin Frauenknecht; Clemencia Pinilla; Radleigh Santos; Christian Hammer; Yaneth Ortiz; Lennart Opitz; Hans Grönlund; Gerhard Rogler; Onur Boyman; Richard Reynolds; Andreas Lutterotti; Mohsen Khademi; Tomas Olsson; Fredrik Piehl; Mireia Sospedra; Roland Martin
Journal:  Cell       Date:  2018-08-30       Impact factor: 41.582

7.  Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis.

Authors:  Max Kaufmann; Hayley Evans; Anna-Lena Schaupp; Jan Broder Engler; Gurman Kaur; Anne Willing; Nina Kursawe; Charlotte Schubert; Kathrine E Attfield; Lars Fugger; Manuel A Friese
Journal:  Med (N Y)       Date:  2021-03-12

8.  The discovery of natalizumab, a potent therapeutic for multiple sclerosis.

Authors:  Lawrence Steinman
Journal:  J Cell Biol       Date:  2012-10-29       Impact factor: 10.539

Review 9.  Epstein-Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies.

Authors:  Amit Bar-Or; Michael P Pender; Rajiv Khanna; Lawrence Steinman; Hans-Peter Hartung; Tap Maniar; Ed Croze; Blake T Aftab; Gavin Giovannoni; Manher A Joshi
Journal:  Trends Mol Med       Date:  2019-12-17       Impact factor: 11.951
  9 in total

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