Alexandra T Black1, Arash H Lahouti2, Iskender S Genco3, Matvey Yagudayev1, Bryan C Markinson4, William D Spielfogel1. 1. Department of Orthopedics, Lenox Hill Hospital Northwell, New York, New York, USA. 2. Department of Pathology, Lenox Hill Hospital Northwell, New York, New York, USA. 3. Department of Pathology and Laboratory Medicine, Lenox Hill Hospital Northwell, New York, New York, USA. 4. The Leni and Peter W. May Department of Orthopedic Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Abstract
INTRODUCTION: Amelanotic melanoma is a rare subtype, which may be clinically difficult to diagnose due to lack of pigmentation and variable histopathological features. Osteoinvasion is another rare characteristic of melanoma. There are few reports in the literature of amelanotic melanoma of the nail unit (nail bed, matrix, and nail folds) with invasion of bone. CASE PRESENTATION: We present a case of a 73-year-old Caucasian male with a 13-month history of an ungual lesion on his right hallux. The lesion was initially treated as a chronic diabetic ulceration with failure to resolve with standard of care. DISCUSSION/ CONCLUSION: A heightened index of suspicion for a malignant process is necessary when standard of care fails to lead to improvement or resolution. In these instances, biopsy should be seriously considered.
INTRODUCTION: Amelanotic melanoma is a rare subtype, which may be clinically difficult to diagnose due to lack of pigmentation and variable histopathological features. Osteoinvasion is another rare characteristic of melanoma. There are few reports in the literature of amelanotic melanoma of the nail unit (nail bed, matrix, and nail folds) with invasion of bone. CASE PRESENTATION: We present a case of a 73-year-old Caucasian male with a 13-month history of an ungual lesion on his right hallux. The lesion was initially treated as a chronic diabetic ulceration with failure to resolve with standard of care. DISCUSSION/ CONCLUSION: A heightened index of suspicion for a malignant process is necessary when standard of care fails to lead to improvement or resolution. In these instances, biopsy should be seriously considered.
Authors: Jun Young Kim; Han Jin Jung; Weon Ju Lee; Do Won Kim; Ghil Suk Yoon; Dong-Sun Kim; Mae Ja Park; Seok-Jong Lee Journal: Dermatology Date: 2011-08-16 Impact factor: 5.366
Authors: Carrie P Gosselink; Joseph L Sindone; Bernard J Meadows; Amir Mohammadi; Marilin Rosa Journal: J Foot Ankle Surg Date: 2009 Mar-Apr Impact factor: 1.286
Authors: Ivan R Bristow; David Ar de Berker; Katharine M Acland; Richard J Turner; Jonathan Bowling Journal: J Foot Ankle Res Date: 2010-11-01 Impact factor: 2.303
Authors: Kong-Bing Tan; Marc Moncrieff; John F Thompson; Stanley W McCarthy; Helen M Shaw; Michael J Quinn; Ling-Xi Lawrence Li; Kerry A Crotty; Jonathan R Stretch; Richard A Scolyer Journal: Am J Surg Pathol Date: 2007-12 Impact factor: 6.394
Authors: Nieves Gómez-León; Vilma Pacheco-Barcia; Ana I Ballesteros; Javier Fraga; Ramon Colomer; Alfonsa Friera Journal: Melanoma Res Date: 2018-12 Impact factor: 3.599
Authors: Alexey V Lyundup; Maxim V Balyasin; Nadezhda V Maksimova; Marina V Kovina; Mikhail E Krasheninnikov; Tatiana G Dyuzheva; Sergey A Yakovenko; Svetlana A Appolonova; Helgi B Schiöth; Ilya D Klabukov Journal: Int Wound J Date: 2021-10-29 Impact factor: 3.099