Emma Duignan1, Roderick O'Day1, Thomas Moloney1, Waheeda Rahman1, Bertil Damato1,2. 1. Ophthalmology Department, Moorfields Eye Hospital, London, United Kingdom. 2. Nuffield Laboratory of Ophthalmology, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Abstract
OBJECTIVE: To define the characteristics of solitary idiopathic choroiditis (SIC) in a consecutive series of patients and propose a nomenclature change to idiopathic scleroma. MATERIALS AND METHODS: Electronic patient records were retrospectively interrogated to identify all patients diagnosed with SIC between 2002 and 2019 in a tertiary referral ophthalmic hospital in the United Kingdom. RESULTS: Thirty-four eyes of 34 patients were found to have SIC. The mean age at diagnosis was 48 years (range 24-78) and 23 patients (68%) were female. All lesions were located posterior to the equator, most frequently in the inferotemporal quadrant (13 eyes, 38%). The lesions had a mean largest basal diameter of 1.2 ± 0.4 disc diameters (range 0.5-2) and their distance to the optic disc had a mean of 1.2 ± 0.9 disc diameters (range 0-3.3). All lesions were intrascleral on enhanced depth imaging optical coherence tomography, demonstrating a hypo-reflective zone within the sclera, with an underlying hyper-reflective zone in some cases. No lesion enlarged or developed features consistent with active inflammation after a median follow-up time of 0.9 years (range 0-16.8). DISCUSSION/ CONCLUSION: Optical coherence tomography shows SIC to be an intrascleral lesion. Furthermore, we found no evidence of any inflammatory component. A nomenclature change to idiopathic scleroma is appropriate to prevent unnecessary investigation.
OBJECTIVE: To define the characteristics of solitary idiopathic choroiditis (SIC) in a consecutive series of patients and propose a nomenclature change to idiopathic scleroma. MATERIALS AND METHODS: Electronic patient records were retrospectively interrogated to identify all patients diagnosed with SIC between 2002 and 2019 in a tertiary referral ophthalmic hospital in the United Kingdom. RESULTS: Thirty-four eyes of 34 patients were found to have SIC. The mean age at diagnosis was 48 years (range 24-78) and 23 patients (68%) were female. All lesions were located posterior to the equator, most frequently in the inferotemporal quadrant (13 eyes, 38%). The lesions had a mean largest basal diameter of 1.2 ± 0.4 disc diameters (range 0.5-2) and their distance to the optic disc had a mean of 1.2 ± 0.9 disc diameters (range 0-3.3). All lesions were intrascleral on enhanced depth imaging optical coherence tomography, demonstrating a hypo-reflective zone within the sclera, with an underlying hyper-reflective zone in some cases. No lesion enlarged or developed features consistent with active inflammation after a median follow-up time of 0.9 years (range 0-16.8). DISCUSSION/ CONCLUSION: Optical coherence tomography shows SIC to be an intrascleral lesion. Furthermore, we found no evidence of any inflammatory component. A nomenclature change to idiopathic scleroma is appropriate to prevent unnecessary investigation.
Authors: Adrian T Fung; Sebastian M Waldstein; Orly Gal-Or; Marco Pellegrini; Chiara Preziosa; Jerry A Shields; R Joel Welch; Rosa Dolz-Marco; David Sarraf; Aaron Nagiel; Robert Lalane; Jesse J Jung; Nicola G Ghazi; Prithvi Ramtohul; Jennifer J Arnold; Yoichi Sakurada; Netan Choudhry; Chandrakumar Balaratnasingam; K Bailey Freund; Carol L Shields Journal: Ophthalmology Date: 2020-04-22 Impact factor: 12.079
Authors: Adrian T Fung; Swathi Kaliki; Carol L Shields; Arman Mashayekhi; Jerry A Shields Journal: Ophthalmology Date: 2012-12-12 Impact factor: 12.079