| Literature DB >> 33795875 |
Yang Yi1, Yanqiang Li2,3,4, Qingshu Meng1, Qiaqia Li1, Fuxi Li5,6, Bing Lu5,6, Jiangchuan Shen7, Ladan Fazli8,9, Dongyu Zhao2,3,4, Chao Li1, Weihua Jiang10, Rui Wang10, Qipeng Liu10, Aileen Szczepanski11, Qianru Li12, Wei Qin13, Adam B Weiner1, Tamara L Lotan14, Zhe Ji12,15, Sundeep Kalantry16, Lu Wang11, Edward M Schaeffer1, Hengyao Niu7, Xuesen Dong8,9, Wei Zhao5,6, Kaifu Chen17,18,19, Qi Cao20,21.
Abstract
Dysregulated translation is a common feature of cancer. Uncovering its governing factors and underlying mechanism are important for cancer therapy. Here, we report that enhancer of zeste homologue 2 (EZH2), previously known as a transcription repressor and lysine methyltransferase, can directly interact with fibrillarin (FBL) to exert its role in translational regulation. We demonstrate that EZH2 enhances rRNA 2'-O methylation via its direct interaction with FBL. Mechanistically, EZH2 strengthens the FBL-NOP56 interaction and facilitates the assembly of box C/D small nucleolar ribonucleoprotein. Strikingly, EZH2 deficiency impairs the translation process globally and reduces internal ribosome entry site (IRES)-dependent translation initiation in cancer cells. Our findings reveal a previously unrecognized role of EZH2 in cancer-related translational regulation.Entities:
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Year: 2021 PMID： 33795875 PMCID： PMC8162121 DOI： 10.1038/s41556-021-00653-6
Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.213