Literature DB >> 33794649

Concordance of a High Polygenic Score Among Relatives: Implications for Genetic Counseling and Cascade Screening.

Nicholas J Reid1,2, Deanna G Brockman3,1, Courtney Elisabeth Leonard3,1, Renee Pelletier3,1, Amit V Khera3,1,2.   

Abstract

Entities:  

Keywords:  cognition; genetics; humans; obesity; phenotype

Mesh：

Year:  2021        PMID： 33794649      PMCID： PMC8058306          DOI： 10.1161/CIRCGEN.120.003262

Source DB:  PubMed          Journal:  Circ Genom Precis Med        ISSN： 2574-8300


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  5 in total

1.  Screening Human Embryos for Polygenic Traits Has Limited Utility.

Authors:  Ehud Karavani; Or Zuk; Danny Zeevi; Nir Barzilai; Nikos C Stefanis; Alex Hatzimanolis; Nikolaos Smyrnis; Dimitrios Avramopoulos; Leonid Kruglyak; Gil Atzmon; Max Lam; Todd Lencz; Shai Carmi
Journal:  Cell       Date:  2019-11-21       Impact factor: 41.582

2.  Whole-Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized With Early-Onset Myocardial Infarction.

Authors:  Amit V Khera; Mark Chaffin; Seyedeh M Zekavat; Ryan L Collins; Carolina Roselli; Pradeep Natarajan; Judith H Lichtman; Gail D'Onofrio; Jennifer Mattera; Rachel Dreyer; John A Spertus; Kent D Taylor; Bruce M Psaty; Stephen S Rich; Wendy Post; Namrata Gupta; Stacey Gabriel; Eric Lander; Yii-Der Ida Chen; Michael E Talkowski; Jerome I Rotter; Harlan M Krumholz; Sekar Kathiresan
Journal:  Circulation       Date:  2019-03-26       Impact factor: 29.690

3.  Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.

Authors:  Amit V Khera; Mark Chaffin; Kaitlin H Wade; Sohail Zahid; Joseph Brancale; Rui Xia; Marina Distefano; Ozlem Senol-Cosar; Mary E Haas; Alexander Bick; Krishna G Aragam; Eric S Lander; George Davey Smith; Heather Mason-Suares; Myriam Fornage; Matthew Lebo; Nicholas J Timpson; Lee M Kaplan; Sekar Kathiresan
Journal:  Cell       Date:  2019-04-18       Impact factor: 66.850

4.  Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.

Authors:  Amit V Khera; Mark Chaffin; Krishna G Aragam; Mary E Haas; Carolina Roselli; Seung Hoan Choi; Pradeep Natarajan; Eric S Lander; Steven A Lubitz; Patrick T Ellinor; Sekar Kathiresan
Journal:  Nat Genet       Date:  2018-08-13       Impact factor: 38.330

5.  The UK Biobank resource with deep phenotyping and genomic data.

Authors:  Clare Bycroft; Colin Freeman; Desislava Petkova; Gavin Band; Lloyd T Elliott; Kevin Sharp; Allan Motyer; Damjan Vukcevic; Olivier Delaneau; Jared O'Connell; Adrian Cortes; Samantha Welsh; Alan Young; Mark Effingham; Gil McVean; Stephen Leslie; Naomi Allen; Peter Donnelly; Jonathan Marchini
Journal:  Nature       Date:  2018-10-10       Impact factor: 49.962
  5 in total
  1 in total

1.  New prevention scenarios: polygenic risk.

Authors:  Alessandro Boccanelli; Giordano Bottà
Journal:  Eur Heart J Suppl       Date:  2021-10-08       Impact factor: 1.803
  1 in total

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