Literature DB >> 3379411

Sequence of two mRNAs encoding active rat tryptophan hydroxylase.

M C Darmon1, B Guibert, V Leviel, M Ehret, M Maitre, J Mallet.   

Abstract

Two full-length cDNA clones that encode functional rat tryptophan hydroxylase (EC 1.14.16.4), the key enzyme in serotonin synthesis, have been isolated from a rat pineal gland library. These two clones correspond to the 1.8- and 4-kilobase mRNA species, respectively. They contain the same coding sequence corresponding to a 51,010-dalton protein and differ in the length of their 3' untranslated regions.

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Year:  1988        PMID： 3379411     DOI： 10.1111/j.1471-4159.1988.tb04871.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  15 in total

1.  Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos.

Authors:  H Teraoka; C Russell; J Regan; A Chandrasekhar; M L Concha; R Yokoyama; K Higashi; M Take-Uchi; W Dong; T Hiraga; N Holder; S W Wilson
Journal:  J Neurobiol       Date:  2004-09-05

2.  Complete coding sequence of human tryptophan hydroxylase.

Authors:  S Boularand; M C Darmon; Y Ganem; J M Launay; J Mallet
Journal:  Nucleic Acids Res       Date:  1990-07-25       Impact factor: 16.971

3.  An efficient strategy for cloning 5' extremities of rare transcripts permits isolation of multiple 5'-untranslated regions of rat tryptophan hydroxylase mRNA.

Authors:  J Delort; J B Dumas; M C Darmon; J Mallet
Journal:  Nucleic Acids Res       Date:  1989-08-25       Impact factor: 16.971

Review 4.  Structure and function of the aromatic amino acid hydroxylases.

Authors:  S E Hufton; I G Jennings; R G Cotton
Journal:  Biochem J       Date:  1995-10-15       Impact factor: 3.857

5.  Dopamine inactivates tryptophan hydroxylase and forms a redox-cycling quinoprotein: possible endogenous toxin to serotonin neurons.

Authors:  D M Kuhn; R Arthur
Journal:  J Neurosci       Date:  1998-09-15       Impact factor: 6.167

6.  Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function.

Authors:  Francine Côté; Etienne Thévenot; Cécile Fligny; Yves Fromes; Michèle Darmon; Marie-Anne Ripoche; Elisa Bayard; Naima Hanoun; Francoise Saurini; Philippe Lechat; Luisa Dandolo; Michel Hamon; Jacques Mallet; Guilan Vodjdani
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-03       Impact factor: 11.205

7.  Ovarian steroid regulation of tryptophan hydroxylase mRNA expression in rhesus macaques.

Authors:  M Pecins-Thompson; N A Brown; S G Kohama; C L Bethea
Journal:  J Neurosci       Date:  1996-11-01       Impact factor: 6.167

Review 8.  Advances in the molecular characterization of tryptophan hydroxylase.

Authors:  S M Mockus; K E Vrana
Journal:  J Mol Neurosci       Date:  1998-06       Impact factor: 3.444

9.  Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin.

Authors:  H J Cho; E Martin; Q W Xie; S Sassa; C Nathan
Journal:  Proc Natl Acad Sci U S A       Date:  1995-12-05       Impact factor: 11.205

10.  High-level expression and deletion mutagenesis of human tryptophan hydroxylase.

Authors:  X J Yang; S Kaufman
Journal:  Proc Natl Acad Sci U S A       Date:  1994-07-05       Impact factor: 11.205
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