Literature DB >> 33792343

HSP25 Vaccination Attenuates Atherogenesis via Upregulation of LDLR Expression, Lowering of PCSK9 Levels and Curbing of Inflammation.

Yong-Xiang Chen1, Chunhua Shi1, Jingti Deng1, Catherine Diao1, Nadia Maarouf1, Matthew Rosin1, Vipul Shrivastava1, Angie A Hu1, Sonya Bharadwa1, Ayinuer Adijiang1, Annegret Ulke-Lemee1, Brenig Gwilym1, Alexandria Hellmich2, Christopher Malozzi3, Zarah Batulan1, Jonathan L E Dean4, F Daniel Ramirez5, Jingwen Liu6, William T Gerthoffer2, Edward R O'Brien1.   

Abstract

[Figure: see text].

Entities:  

Keywords:  HSP27 heat-shock proteins; atherosclerosis; cholesterol; inflammation; proprotein convertases; receptors, LDL; vaccines

Mesh：

Substances：

Year:  2021        PMID： 33792343      PMCID： PMC8159870          DOI： 10.1161/ATVBAHA.121.315933

Source DB:  PubMed          Journal:  Arterioscler Thromb Vasc Biol        ISSN： 1079-5642            Impact factor:   10.514


  40 in total

1.  Heat shock protein 27 immune complex altered signaling and transport (ICAST): Novel mechanisms of attenuating inflammation.

Authors:  Chunhua Shi; Jingti Deng; Michael Chiu; Yong-Xiang Chen; Edward R O'Brien
Journal:  FASEB J       Date:  2020-09-04       Impact factor: 5.191

2.  Overexpression of activated nuclear factor-kappa B in aorta of patients with coronary atherosclerosis.

Authors:  Wei Zhang; Shan Shan Xing; Xue Lin Sun; Qi Chong Xing
Journal:  Clin Cardiol       Date:  2009-12       Impact factor: 2.882

3.  Identification by a differential proteomic approach of heat shock protein 27 as a potential marker of atherosclerosis.

Authors:  Jose Luis Martin-Ventura; Mari Carmen Duran; Luis Miguel Blanco-Colio; Olivier Meilhac; Anne Leclercq; Jean-Baptiste Michel; Ole N Jensen; Sergio Hernandez-Merida; José Tuñón; Fernando Vivanco; Jesús Egido
Journal:  Circulation       Date:  2004-07-12       Impact factor: 29.690

4.  Unlike estrogens that increase PCSK9 levels post-menopause HSP27 vaccination lowers cholesterol levels and atherogenesis due to divergent effects on PCSK9 and LDLR.

Authors:  Nadia Maarouf; Yong-Xiang Chen; Chunhua Shi; Jingti Deng; Catherine Diao; Matthew Rosin; Vipul Shrivastava; Zarah Batulan; Jingwen Liu; Edward R O'Brien
Journal:  Pharmacol Res       Date:  2020-10-03       Impact factor: 7.658

5.  Serum heat shock protein 27 levels represent a potential therapeutic target for atherosclerosis: observations from a human cohort and treatment of female mice.

Authors:  Tara A Seibert; Benjamin Hibbert; Yong-Xiang Chen; Katey Rayner; Trevor Simard; Tieqiang Hu; Charles M Cuerrier; Xiaoling Zhao; Jacqueline de Belleroche; Benjamin J W Chow; Steven Hawken; Kumanan R Wilson; Edward R O'Brien
Journal:  J Am Coll Cardiol       Date:  2013-06-10       Impact factor: 24.094

6.  Antibody titres to heat shock protein 27 are elevated in patients with acute coronary syndrome.

Authors:  Majid Ghayour-Mobarhan; Amirhossein Sahebkar; Seyyed Mohammad Reza Parizadeh; Mohsen Moohebati; Shima Tavallaie; Seyyed Mohammad Rezakazemi-Bajestani; Habib-Allah Esmaeili; Gordon Ferns
Journal:  Int J Exp Pathol       Date:  2008-06       Impact factor: 1.925

7.  Heat shock protein 27 protects against atherogenesis via an estrogen-dependent mechanism: role of selective estrogen receptor beta modulation.

Authors:  Katey Rayner; Jiangfeng Sun; Yong-Xiang Chen; Melissa McNulty; Trevor Simard; Xiaoling Zhao; Dominic J Wells; Jacqueline de Belleroche; Edward R O'Brien
Journal:  Arterioscler Thromb Vasc Biol       Date:  2009-09-03       Impact factor: 8.311

8.  Identification of a New Broadly Cross-reactive Epitope within Domain III of the Duck Tembusu Virus E Protein.

Authors:  Chenxi Li; Xiaofei Bai; Runze Meng; Wulin Shaozhou; Qingshan Zhang; Ronghong Hua; Jyung-Hurng Liu; Ming Liu; Yun Zhang
Journal:  Sci Rep       Date:  2016-11-08       Impact factor: 4.379

Review 9.  Natural antibodies - facts known and unknown.

Authors:  Joanna Palma; Beata Tokarz-Deptuła; Jakub Deptuła; Wiesław Deptuła
Journal:  Cent Eur J Immunol       Date:  2018-12-31       Impact factor: 2.085

10.  The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden.CETP mice.

Authors:  Christine Landlinger; Marianne G Pouwer; Claudia Juno; José W A van der Hoorn; Elsbet J Pieterman; J Wouter Jukema; Guenther Staffler; Hans M G Princen; Gergana Galabova
Journal:  Eur Heart J       Date:  2017-08-21       Impact factor: 29.983
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